| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10046896 | HBV | ENSG00000115705.22 | protein_coding | TPO | No | No | 7173 | P07202 Q502Y3 Q6P534 |
| TVIS20007279 | HPV | ENSG00000115705.22 | protein_coding | TPO | No | No | 7173 | P07202 Q502Y3 Q6P534 |
| TVIS20005425 | HPV | ENSG00000115705.22 | protein_coding | TPO | No | No | 7173 | P07202 Q502Y3 Q6P534 |
| TVIS20042386 | HPV | ENSG00000115705.22 | protein_coding | TPO | No | No | 7173 | P07202 Q502Y3 Q6P534 |
| TVIS20040873 | HPV | ENSG00000115705.22 | protein_coding | TPO | No | No | 7173 | P07202 Q502Y3 Q6P534 |
| TVIS20023692 | HPV | ENSG00000115705.22 | protein_coding | TPO | No | No | 7173 | P07202 Q502Y3 Q6P534 |
| TVIS44015773 | HTLV-1 | ENSG00000115705.22 | protein_coding | TPO | No | No | 7173 | P07202 Q502Y3 Q6P534 |
| TVIS44008995 | HTLV-1 | ENSG00000115705.22 | protein_coding | TPO | No | No | 7173 | P07202 Q502Y3 Q6P534 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TPO |
|---|---|
| DrugBank ID | DB00550 |
| Drug Name | Propylthiouracil |
| Target ID | BE0000507 |
| UniProt ID | P07202 |
| Regulation Type | inhibitor |
| PubMed IDs | 10365684; 11241400; 12755690; 17379648; 2656250; 11752352 |
| Citations | Sugawara M, Sugawara Y, Wen K: Methimazole and propylthiouracil increase cellular thyroid peroxidase activity and thyroid peroxidase mRNA in cultured porcine thyroid follicles. Thyroid. 1999 May;9(5):513-8.@@Manzon RG, Holmes JA, Youson JH: Variable effects of goitrogens in inducing precocious metamorphosis in sea lampreys (Petromyzon marinus). J Exp Zool. 2001 Apr 15;289(5):290-303.@@Ferreira AC, de Carvalho Cardoso L, Rosenthal D, de Carvalho DP: Thyroid Ca2+/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole. Eur J Biochem. 2003 Jun;270(11):2363-8.@@Schmutzler C, Bacinski A, Gotthardt I, Huhne K, Ambrugger P, Klammer H, Schlecht C, Hoang-Vu C, Gruters A, Wuttke W, Jarry H, Kohrle J: The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase. Endocrinology. 2007 Jun;148(6):2835-44. Epub 2007 Mar 22.@@Taurog A, Dorris ML: A reexamination of the proposed inactivation of thyroid peroxidase in the rat thyroid by propylthiouracil. Endocrinology. 1989 Jun;124(6):3038-42.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational |
| Direct Classification | Pyrimidones |
| SMILES | CCCC1=CC(=O)NC(=S)N1 |
| Pathways | |
| PharmGKB | PA451156 |
| ChEMBL | CHEMBL1518 |
