| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20020006 | HPV | ENSG00000179097.7 | protein_coding | HTR1F | No | No | 3355 | P30939 |
| TVIS20020007 | HPV | ENSG00000179097.7 | protein_coding | HTR1F | No | No | 3355 | P30939 |
| TVIS44019173 | HTLV-1 | ENSG00000179097.7 | protein_coding | HTR1F | No | No | 3355 | P30939 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | HTR1F |
|---|---|
| DrugBank ID | DB00669 |
| Drug Name | Sumatriptan |
| Target ID | BE0000460 |
| UniProt ID | P30939 |
| Regulation Type | agonist |
| PubMed IDs | 10073743; 10367177; 11015308; 15178373; 11752352; 10225363; 18723285; 12110114 |
| Citations | Razzaque Z, Heald MA, Pickard JD, Maskell L, Beer MS, Hill RG, Longmore J: Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation. Br J Clin Pharmacol. 1999 Jan;47(1):75-82.@@Pauwels PJ, John GW: Present and future of 5-HT receptor agonists as antimigraine drugs. Clin Neuropharmacol. 1999 May-Jun;22(3):123-36.@@Cohen ML, Schenck K: Contractile responses to sumatriptan and ergotamine in the rabbit saphenous vein: effect of selective 5-HT(1F) receptor agonists and PGF(2alpha). Br J Pharmacol. 2000 Oct;131(3):562-8.@@Janssen P, Tack J, Sifrim D, Meulemans AL, Lefebvre RA: Influence of 5-HT1 receptor agonists on feline stomach relaxation. Eur J Pharmacol. 2004 May 25;492(2-3):259-67.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Mitsikostas DD, Sanchez del Rio M, Moskowitz MA, Waeber C: Both 5-HT1B and 5-HT1F receptors modulate c-fos expression within rat trigeminal nucleus caudalis. Eur J Pharmacol. 1999 Mar 26;369(3):271-7.@@Nikai T, Basbaum AI, Ahn AH: Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan. Pain. 2008 Oct 31;139(3):533-40. doi: 10.1016/j.pain.2008.06.002. Epub 2008 Aug 23.@@Mitsikostas DD, Sanchez del Rio M, Waeber C: 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis. Cephalalgia. 2002 Jun;22(5):384-94. |
| Groups | Approved; Investigational |
| Direct Classification | Tryptamines and derivatives |
| SMILES | CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 |
| Pathways | |
| PharmGKB | PA451566 |
| ChEMBL | CHEMBL128 |
