| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10035131 | HBV | ENSG00000074803.21 | protein_coding | SLC12A1 | No | No | 6557 | Q13621 Q8IUN5 |
| TVIS20002358 | HPV | ENSG00000074803.21 | protein_coding | SLC12A1 | No | No | 6557 | Q13621 Q8IUN5 |
| TVIS20038461 | HPV | ENSG00000074803.21 | protein_coding | SLC12A1 | No | No | 6557 | Q13621 Q8IUN5 |
| TVIS20052244 | HPV | ENSG00000074803.21 | protein_coding | SLC12A1 | No | No | 6557 | Q13621 Q8IUN5 |
| TVIS20025243 | HPV | ENSG00000074803.21 | protein_coding | SLC12A1 | No | No | 6557 | Q13621 Q8IUN5 |
| TVIS44002636 | HTLV-1 | ENSG00000074803.21 | protein_coding | SLC12A1 | No | No | 6557 | Q13621 Q8IUN5 |
| TVIS44029374 | HTLV-1 | ENSG00000074803.21 | protein_coding | SLC12A1 | No | No | 6557 | Q13621 Q8IUN5 |
| TVIS44010135 | HTLV-1 | ENSG00000074803.21 | protein_coding | SLC12A1 | No | No | 6557 | Q13621 Q8IUN5 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SLC12A1 |
|---|---|
| DrugBank ID | DB00695 |
| Drug Name | Furosemide |
| Target ID | BE0000502 |
| UniProt ID | Q13621 |
| Regulation Type | inhibitor |
| PubMed IDs | 10653443; 1092541; 17460608; 11752352; 16914965; 26183401 |
| Citations | Brater DC: Pharmacology of diuretics. Am J Med Sci. 2000 Jan;319(1):38-50.@@Davies DL, Wilson GM: Diuretics: mechanism of action and clinical application. Drugs. 1975;9(3):178-226.@@Vormfelde SV, Sehrt D, Toliat MR, Schirmer M, Meineke I, Tzvetkov M, Nurnberg P, Brockmoller J: Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs. Clin Pharmacol Ther. 2007 Sep;82(3):300-9. Epub 2007 Apr 25.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Gimenez I: Molecular mechanisms and regulation of furosemide-sensitive Na-K-Cl cotransporters. Curr Opin Nephrol Hypertens. 2006 Sep;15(5):517-23. doi: 10.1097/01.mnh.0000242178.44576.b0.@@Limmer F, Schinner E, Castrop H, Vitzthum H, Hofmann F, Schlossmann J: Regulation of the Na(+)-K(+)-2Cl(-) cotransporter by cGMP/cGMP-dependent protein kinase I after furosemide administration. FEBS J. 2015 Oct;282(19):3786-98. doi: 10.1111/febs.13376. Epub 2015 Jul 30. |
| Groups | Approved; Vet_approved |
| Direct Classification | Aminobenzenesulfonamides |
| SMILES | NS(=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C(O)=O |
| Pathways | Furosemide Action Pathway |
| PharmGKB | PA449719 |
| ChEMBL | CHEMBL35 |
