| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30077620 | HIV | ENSG00000100346.18 | protein_coding | CACNA1I | No | No | 8911 | Q9P0X4 |
| TVIS20021084 | HPV | ENSG00000100346.18 | protein_coding | CACNA1I | No | No | 8911 | Q9P0X4 |
| TVIS44018379 | HTLV-1 | ENSG00000100346.18 | protein_coding | CACNA1I | No | No | 8911 | Q9P0X4 |
| TVIS44021514 | HTLV-1 | ENSG00000100346.18 | protein_coding | CACNA1I | No | No | 8911 | Q9P0X4 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | CACNA1I |
|---|---|
| DrugBank ID | DB04841 |
| Drug Name | Flunarizine |
| Target ID | BE0000012 |
| UniProt ID | Q9P0X4 |
| Regulation Type | inhibitor |
| PubMed IDs | 17139284; 17016423; 19582593; 11784784 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Uebele VN, Nuss CE, Fox SV, Garson SL, Cristescu R, Doran SM, Kraus RL, Santarelli VP, Li Y, Barrow JC, Yang ZQ, Schlegel KA, Rittle KE, Reger TS, Bednar RA, Lemaire W, Mullen FA, Ballard JE, Tang C, Dai G, McManus OB, Koblan KS, Renger JJ: Positive allosteric interaction of structurally diverse T-type calcium channel antagonists. Cell Biochem Biophys. 2009;55(2):81-93. doi: 10.1007/s12013-009-9057-4. Epub 2009 Jul 7.@@Santi CM, Cayabyab FS, Sutton KG, McRory JE, Mezeyova J, Hamming KS, Parker D, Stea A, Snutch TP: Differential inhibition of T-type calcium channels by neuroleptics. J Neurosci. 2002 Jan 15;22(2):396-403. |
| Groups | Approved |
| Direct Classification | Diphenylmethanes |
| SMILES | FC1=CC=C(C=C1)C(N1CCN(CC=CC2=CC=CC=C2)CC1)C1=CC=C(F)C=C1 |
| Pathways | Flunarizine H1-Antihistamine Action |
| PharmGKB | PA164776636 |
| ChEMBL | CHEMBL30008 |
