| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS42000535 | EBV | ENSG00000196557.14 | protein_coding | CACNA1H | No | No | 8912 | A0A1W2PQW2 O95180 |
| TVIS30079906 | HIV | ENSG00000196557.14 | protein_coding | CACNA1H | No | No | 8912 | A0A1W2PQW2 O95180 |
| TVIS30083071 | HIV | ENSG00000196557.14 | protein_coding | CACNA1H | No | No | 8912 | A0A1W2PQW2 O95180 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CACNA1H |
|---|---|
| DrugBank ID | DB01388 |
| Drug Name | Mibefradil |
| Target ID | BE0000864 |
| UniProt ID | O95180 |
| Regulation Type | inhibitor |
| PubMed IDs | 15498818; 17190903; 9670923; 16899990; 14993472; 9375939; 9481612; 15562257 |
| Citations | Brueggemann LI, Martin BL, Barakat J, Byron KL, Cribbs LL: Low voltage-activated calcium channels in vascular smooth muscle: T-type channels and AVP-stimulated calcium spiking. Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H923-35. Epub 2004 Oct 21.@@Coste B, Crest M, Delmas P: Pharmacological dissection and distribution of NaN/Nav1.9, T-type Ca2+ currents, and mechanically activated cation currents in different populations of DRG neurons. J Gen Physiol. 2007 Jan;129(1):57-77.@@Cribbs LL, Lee JH, Yang J, Satin J, Zhang Y, Daud A, Barclay J, Williamson MP, Fox M, Rees M, Perez-Reyes E: Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family. Circ Res. 1998 Jul 13;83(1):103-9.@@Lee TS, Kaku T, Takebayashi S, Uchino T, Miyamoto S, Hadama T, Perez-Reyes E, Ono K: Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. Epub 2006 Aug 7.@@Perez-Reyes E: Paradoxical role of T-type calcium channels in coronary smooth muscle. Mol Interv. 2004 Feb;4(1):16-8.@@Massie BM: Mibefradil: a selective T-type calcium antagonist. Am J Cardiol. 1997 Nov 6;80(9A):23I-32I.@@Clozel JP, Ertel EA, Ertel SI: Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker. J Hypertens Suppl. 1997 Dec;15(5):S17-25.@@McNulty MM, Hanck DA: State-dependent mibefradil block of Na+ channels. Mol Pharmacol. 2004 Dec;66(6):1652-61. |
| Groups | Investigational; Withdrawn |
| Direct Classification | Tetralins |
| SMILES | COCC(=O)O[C@]1(CCN(C)CCCC2=NC3=CC=CC=C3N2)CCC2=C(C=CC(F)=C2)[C@@H]1C(C)C |
| Pathways | |
| PharmGKB | PA450492 |
| ChEMBL | CHEMBL45816 |
