| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20050998 | HPV | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
| TVIS20065483 | HPV | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
| TVIS44031243 | HTLV-1 | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
| TVIS44008044 | HTLV-1 | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
| TVIS44020668 | HTLV-1 | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
| TVIS44036283 | HTLV-1 | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | FLT3 |
|---|---|
| DrugBank ID | DB00398 |
| Drug Name | Sorafenib |
| Target ID | BE0000147 |
| UniProt ID | P36888 |
| Regulation Type | inhibitor |
| PubMed IDs | 17205056; 17229632; 20586710 |
| Citations | Auclair D, Miller D, Yatsula V, Pickett W, Carter C, Chang Y, Zhang X, Wilkie D, Burd A, Shi H, Rocks S, Gedrich R, Abriola L, Vasavada H, Lynch M, Dumas J, Trail PA, Wilhelm SM: Antitumor activity of sorafenib in FLT3-driven leukemic cells. Leukemia. 2007 Mar;21(3):439-45. Epub 2007 Jan 4.@@Lierman E, Lahortiga I, Van Miegroet H, Mentens N, Marynen P, Cools J: The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors. Haematologica. 2007 Jan;92(1):27-34.@@Iyer R, Fetterly G, Lugade A, Thanavala Y: Sorafenib: a clinical and pharmacologic review. Expert Opin Pharmacother. 2010 Aug;11(11):1943-55. doi: 10.1517/14656566.2010.496453. |
| Groups | Approved; Investigational |
| Direct Classification | Diarylethers |
| SMILES | CNC(=O)C1=NC=CC(OC2=CC=C(NC(=O)NC3=CC(=C(Cl)C=C3)C(F)(F)F)C=C2)=C1 |
| Pathways | Sorafenib Metabolism Pathway |
| PharmGKB | PA7000 |
| ChEMBL | CHEMBL1336 |
