| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20050998 | HPV | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
| TVIS20065483 | HPV | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
| TVIS44031243 | HTLV-1 | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
| TVIS44008044 | HTLV-1 | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
| TVIS44020668 | HTLV-1 | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
| TVIS44036283 | HTLV-1 | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | FLT3 |
|---|---|
| DrugBank ID | DB01268 |
| Drug Name | Sunitinib |
| Target ID | BE0000147 |
| UniProt ID | P36888 |
| Regulation Type | inhibitor |
| PubMed IDs | 12531805; 14654525; 14753710; 15180525; 15304385; 11752352 |
| Citations | O'Farrell AM, Abrams TJ, Yuen HA, Ngai TJ, Louie SG, Yee KW, Wong LM, Hong W, Lee LB, Town A, Smolich BD, Manning WC, Murray LJ, Heinrich MC, Cherrington JM: SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 2003 May 1;101(9):3597-605. Epub 2003 Jan 16.@@O'Farrell AM, Foran JM, Fiedler W, Serve H, Paquette RL, Cooper MA, Yuen HA, Louie SG, Kim H, Nicholas S, Heinrich MC, Berdel WE, Bello C, Jacobs M, Scigalla P, Manning WC, Kelsey S, Cherrington JM: An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients. Clin Cancer Res. 2003 Nov 15;9(15):5465-76.@@Baratte S, Sarati S, Frigerio E, James CA, Ye C, Zhang Q: Quantitation of SU1 1248, an oral multi-target tyrosine kinase inhibitor, and its metabolite in monkey tissues by liquid chromatograph with tandem mass spectrometry following semi-automated liquid-liquid extraction. J Chromatogr A. 2004 Jan 23;1024(1-2):87-94.@@Schmidt-Arras D, Schwable J, Bohmer FD, Serve H: Flt3 receptor tyrosine kinase as a drug target in leukemia. Curr Pharm Des. 2004;10(16):1867-83.@@Yee KW, Schittenhelm M, O'Farrell AM, Town AR, McGreevey L, Bainbridge T, Cherrington JM, Heinrich MC: Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD-positive leukemic cells. Blood. 2004 Dec 15;104(13):4202-9. Epub 2004 Aug 10.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational |
| Direct Classification | Indolines |
| SMILES | CCN(CC)CCNC(=O)C1=C(C)NC(C=C2/C(=O)NC3=C2C=C(F)C=C3)=C1C |
| Pathways | |
| PharmGKB | PA162372840 |
| ChEMBL | CHEMBL535 |
