| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20050998 | HPV | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
| TVIS20065483 | HPV | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
| TVIS44031243 | HTLV-1 | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
| TVIS44008044 | HTLV-1 | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
| TVIS44020668 | HTLV-1 | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
| TVIS44036283 | HTLV-1 | ENSG00000122025.15 | protein_coding | FLT3 | Yes | No | 2322 | P36888 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | FLT3 |
|---|---|
| DrugBank ID | DB12267 |
| Drug Name | Brigatinib |
| Target ID | BE0000147 |
| UniProt ID | P36888 |
| Regulation Type | inhibitor |
| PubMed IDs | 23239810; 28597393 |
| Citations | Ceccon M, Mologni L, Bisson W, Scapozza L, Gambacorti-Passerini C: Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors. Mol Cancer Res. 2013 Feb;11(2):122-32. doi: 10.1158/1541-7786.MCR-12-0569. Epub 2012 Dec 13.@@Markham A: Brigatinib: First Global Approval. Drugs. 2017 Jul;77(10):1131-1135. doi: 10.1007/s40265-017-0776-3. |
| Groups | Approved; Investigational |
| Direct Classification | Phenylpiperidines |
| SMILES | COC1=CC(=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1)N1CCC(CC1)N1CCN(C)CC1 |
| Pathways | |
| PharmGKB | PA166163482 |
| ChEMBL | CHEMBL3545311 |
