| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20017104 | HPV | ENSG00000134853.12 | protein_coding | PDGFRA | Yes | No | 5156 | P16234 |
| TVIS20058559 | HPV | ENSG00000134853.12 | protein_coding | PDGFRA | Yes | No | 5156 | P16234 |
| TVIS44048880 | HTLV-1 | ENSG00000134853.12 | protein_coding | PDGFRA | Yes | No | 5156 | P16234 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PDGFRA |
|---|---|
| DrugBank ID | DB00619 |
| Drug Name | Imatinib |
| Target ID | BE0000852 |
| UniProt ID | P16234 |
| Regulation Type | antagonist |
| PubMed IDs | 15894928; 15921304; 15928335; 15946589; 15995325 |
| Citations | Yi ES, Strong CR, Piao Z, Perucho M, Weidner N: Epithelioid gastrointestinal stromal tumor with PDGFRA activating mutation and immunoreactivity. Appl Immunohistochem Mol Morphol. 2005 Jun;13(2):157-61.@@Borbenyi Z: [Disorders with eosinophilia, treatment of hypereosinophilic syndrome]. Orv Hetil. 2005 May 1;146(18 Suppl 1):911-6.@@Corless CL, Schroeder A, Griffith D, Town A, McGreevey L, Harrell P, Shiraga S, Bainbridge T, Morich J, Heinrich MC: PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. J Clin Oncol. 2005 Aug 10;23(23):5357-64. Epub 2005 May 31.@@Chen LL, Sabripour M, Andtbacka RH, Patel SR, Feig BW, Macapinlac HA, Choi H, Wu EF, Frazier ML, Benjamin RS: Imatinib resistance in gastrointestinal stromal tumors. Curr Oncol Rep. 2005 Jul;7(4):293-9.@@Tefferi A: Modern diagnosis and treatment of primary eosinophilia. Acta Haematol. 2005;114(1):52-60. |
| Groups | Approved |
| Direct Classification | Benzanilides |
| SMILES | CN1CCN(CC2=CC=C(C=C2)C(=O)NC2=CC(NC3=NC=CC(=N3)C3=CN=CC=C3)=C(C)C=C2)CC1 |
| Pathways | Imatinib Inhibition of BCR-ABL |
| PharmGKB | PA10804 |
| ChEMBL | CHEMBL941 |
