| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10017714 | HBV | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
| TVIS10015036 | HBV | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
| TVIS10030720 | HBV | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
| TVIS10035479 | HBV | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
| TVIS10018975 | HBV | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
| TVIS10049265 | HBV | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
| TVIS20002315 | HPV | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
| TVIS44045260 | HTLV-1 | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
| TVIS44045289 | HTLV-1 | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PLG |
|---|---|
| DrugBank ID | DB00086 |
| Drug Name | Streptokinase |
| Target ID | BE0000211 |
| UniProt ID | P00747 |
| Regulation Type | activator |
| PubMed IDs | 10569766; 10581996; 10631997; 10664583; 10726310; 11752352 |
| Citations | Caballero AR, Lottenberg R, Johnston KH: Cloning, expression, sequence analysis, and characterization of streptokinases secreted by porcine and equine isolates of Streptococcus equisimilis. Infect Immun. 1999 Dec;67(12):6478-86.@@Alessi MC, Juhan-Vague I: [Thrombolytics and their use]. Rev Prat. 1999 Oct 1;49(15):1654-8.@@Chaudhary A, Vasudha S, Rajagopal K, Komath SS, Garg N, Yadav M, Mande SC, Sahni G: Function of the central domain of streptokinase in substrate plasminogen docking and processing revealed by site-directed mutagenesis. Protein Sci. 1999 Dec;8(12):2791-805.@@Parry MA, Zhang XC, Bode I: Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues. Trends Biochem Sci. 2000 Feb;25(2):53-9.@@Korol'chuk VI, Makohonenko IeM, Sederkhol'm-Vil'iams SA: [Plasminogen binding with decapeptide and polypeptide fragments of streptokinase]. Ukr Biokhim Zh (1999). 1999 Sep-Oct;71(5):51-8.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational |
| Direct Classification | Peptides |
| SMILES | |
| Pathways | Streptokinase Action Pathway |
| PharmGKB | PA164754919 |
| ChEMBL | CHEMBL2108147 |
