| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10017714 | HBV | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
| TVIS10015036 | HBV | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
| TVIS10030720 | HBV | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
| TVIS10035479 | HBV | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
| TVIS10018975 | HBV | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
| TVIS10049265 | HBV | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
| TVIS20002315 | HPV | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
| TVIS44045260 | HTLV-1 | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
| TVIS44045289 | HTLV-1 | ENSG00000122194.20 | protein_coding | PLG | No | No | 5340 | P00747 Q5TEH5 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PLG |
|---|---|
| DrugBank ID | DB00513 |
| Drug Name | Aminocaproic acid |
| Target ID | BE0000211 |
| UniProt ID | P00747 |
| Regulation Type | inhibitor |
| PubMed IDs | 10026282; 11304653; 11927133; 12007600; 1280065; 11752352 |
| Citations | Mochalkin I, Cheng B, Klezovitch O, Scanu AM, Tulinsky A: Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance. Biochemistry. 1999 Feb 16;38(7):1990-8.@@Prandota J, Pankow-Prandota L, Kotecki L: Impaired activation of the fibrinolytic system in children with Henoch-Schonlein purpura: beneficial effect of hydrocortisone plus Sigma-aminocaproic acid therapy on disappearance rate of cutaneous vasculitis and fibrinolysis. Am J Ther. 2001 Jan-Feb;8(1):11-9.@@Lee KN, Jackson KW, McKee PA: Effect of a synthetic carboxy-terminal peptide of alpha(2)-antiplasmin on urokinase-induced fibrinolysis. Thromb Res. 2002 Feb 1;105(3):263-70.@@Sun Z, Chen YH, Wang P, Zhang J, Gurewich V, Zhang P, Liu JN: The blockage of the high-affinity lysine binding sites of plasminogen by EACA significantly inhibits prourokinase-induced plasminogen activation. Biochim Biophys Acta. 2002 Apr 29;1596(2):182-92.@@Kanalas JJ: Analysis of plasmin binding and urokinase activation of plasminogen bound to the Heymann nephritis autoantigen, gp330. Arch Biochem Biophys. 1992 Dec;299(2):255-60.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational |
| Direct Classification | Medium-chain fatty acids |
| SMILES | NCCCCCC(O)=O |
| Pathways | Aminocaproic Acid Action Pathway |
| PharmGKB | PA164774947 |
| ChEMBL | CHEMBL1046 |
