Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for GUCY1A2
Basic gene info.Gene symbolGUCY1A2
Gene nameguanylate cyclase 1, soluble, alpha 2
SynonymsGC-SA2|GUC1A2
CytomapUCSC genome browser: 11q21-q22
Genomic locationchr11 :106544737-106889171
Type of geneprotein-coding
RefGenesNM_000855.2,
NM_001256424.1,
Ensembl idENSG00000152402
DescriptionGCS-alpha-2guanylate cyclase soluble subunit alpha-2
Modification date20141207
dbXrefs MIM : 601244
HGNC : HGNC
Ensembl : ENSG00000152402
HPRD : 03146
Vega : OTTHUMG00000166296
ProteinUniProt: P33402
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GUCY1A2
BioGPS: 2977
Gene Expression Atlas: ENSG00000152402
The Human Protein Atlas: ENSG00000152402
PathwayNCI Pathway Interaction Database: GUCY1A2
KEGG: GUCY1A2
REACTOME: GUCY1A2
ConsensusPathDB
Pathway Commons: GUCY1A2
MetabolismMetaCyc: GUCY1A2
HUMANCyc: GUCY1A2
RegulationEnsembl's Regulation: ENSG00000152402
miRBase: chr11 :106,544,737-106,889,171
TargetScan: NM_000855
cisRED: ENSG00000152402
ContextiHOP: GUCY1A2
cancer metabolism search in PubMed: GUCY1A2
UCL Cancer Institute: GUCY1A2
Assigned class in ccmGDBB - This gene belongs to cancer gene.

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Phenotypic Information for GUCY1A2(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: GUCY1A2
Familial Cancer Database: GUCY1A2
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_PURINE_METABOLISM

check002.gifOthers
OMIM 601244; gene.
Orphanet
DiseaseKEGG Disease: GUCY1A2
MedGen: GUCY1A2 (Human Medical Genetics with Condition)
ClinVar: GUCY1A2
PhenotypeMGI: GUCY1A2 (International Mouse Phenotyping Consortium)
PhenomicDB: GUCY1A2

Mutations for GUCY1A2
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
There's no inter-chromosomal structural variation.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryGUCY1A2chr11106845059106845079GUCY1A2chr11106845123106845143
pancreasGUCY1A2chr11106616795106616815chr11107054834107054854
pancreasGUCY1A2chr11106760443106760463GUCY1A2chr11106761740106761760
pancreasGUCY1A2chr11106760840106761040GUCY1A2chr11106761405106761605
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GUCY1A2 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BG000658GUCY1A2920111106722249106722440MALAT1192427116526673765266972

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample1 1   2 1 1  3  1
GAIN (# sample)1 1       1  1  1
LOSS (# sample)      2 1    2   
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=7

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=136)
Stat. for Synonymous SNVs
(# total SNVs=40)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr11:106558447-106558447p.P676L5
chr11:106558339-106558339p.S712L4
chr11:106849374-106849374p.G153E3
chr11:106558444-106558444p.R677Q3
chr11:106579265-106579265p.R655L3
chr11:106681137-106681137p.P425L3
chr11:106558379-106558379p.V699L3
chr11:106558323-106558323p.K717N3
chr11:106810341-106810341p.R351*3
chr11:106558483-106558483p.?2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample54 19  5 2  25122 22812 10
# mutation54 25  5 2  28132 12713 11
nonsynonymous SNV44 22  4 1  1910  1178 9
synonymous SNV1  3  1 1  932  105 2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr11:106558447p.P676L,GUCY1A23
chr11:106558458p.P425L,GUCY1A22
chr11:106558280p.L732I,GUCY1A22
chr11:106849374p.R136I,GUCY1A22
chr11:106558469p.K128N,GUCY1A22
chr11:106810341p.F672F,GUCY1A22
chr11:106558403p.Y572H,GUCY1A22
chr11:106681097p.E669Q,GUCY1A22
chr11:106647287p.S712L,GUCY1A22
chr11:106681104p.L438L,GUCY1A22

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for GUCY1A2 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for GUCY1A2

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ASPH,DNAJC22,FAM168A,FEM1C,GALNT10,GUCY1A2,KIAA1024,
LINC01105,LOC400940,MIA3,MORC4,NKX3-1,NTNG1,OVCH1,
PAX9,PGM2L1,RIPPLY1,SLC2A13,SLC3A1,TFAP2B,ZNF761
ABCC9,ADAMTSL3,ASAP2,C20orf194,CDC42BPA,EBF2,EML1,
FBN1,GUCY1A2,HEG1,LIMS1,NAV1,NRP1,PCSK5,
PHACTR2,PLXNA2,RBMS3,SAMD8,ZEB1,ZEB2,ZFHX3

ABCG4,ADAMTS3,AVPR1A,CHN1,COL21A1,COL4A1,FAM162B,
GIPC3,GUCY1A2,IMPG2,LOC255167,LOXHD1,LRRC17,MYF5,
NHSL2,OR2AK2,PLEKHG2,RPH3A,SPRED3,TRPC3,XKR5
A4GALT,ARHGAP23,ARHGAP29,ARHGEF10,C1orf198,CADM3,ENAH,
EYA4,FAM63B,GUCY1A2,HIPK3,IL6ST,KCND2,MAP9,
NRXN1,PWAR5,PLEKHA4,PTGIS,RADIL,SCN3B,WTIP
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for GUCY1A2


There's no related Drug.
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Cross referenced IDs for GUCY1A2
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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