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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for POLR2G |
Basic gene info. | Gene symbol | POLR2G |
Gene name | polymerase (RNA) II (DNA directed) polypeptide G | |
Synonyms | RPB19|RPB7|hRPB19|hsRPB7 | |
Cytomap | UCSC genome browser: 11q13.1 | |
Genomic location | chr11 :62529010-62534187 | |
Type of gene | protein-coding | |
RefGenes | NM_002696.2, | |
Ensembl id | ENSG00000168002 | |
Description | DNA directed RNA polymerase II 19 kda polypeptideDNA-directed RNA polymerase II 19 kDa polypeptideDNA-directed RNA polymerase II subunit GDNA-directed RNA polymerase II subunit RPB7RNA polymerase II 19 kDa subunitRNA polymerase II seventh subunitRNA | |
Modification date | 20141207 | |
dbXrefs | MIM : 602013 | |
HGNC : HGNC | ||
Ensembl : ENSG00000168002 | ||
HPRD : 15995 | ||
Vega : OTTHUMG00000167609 | ||
Protein | UniProt: P62487 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_POLR2G | |
BioGPS: 5436 | ||
Gene Expression Atlas: ENSG00000168002 | ||
The Human Protein Atlas: ENSG00000168002 | ||
Pathway | NCI Pathway Interaction Database: POLR2G | |
KEGG: POLR2G | ||
REACTOME: POLR2G | ||
ConsensusPathDB | ||
Pathway Commons: POLR2G | ||
Metabolism | MetaCyc: POLR2G | |
HUMANCyc: POLR2G | ||
Regulation | Ensembl's Regulation: ENSG00000168002 | |
miRBase: chr11 :62,529,010-62,534,187 | ||
TargetScan: NM_002696 | ||
cisRED: ENSG00000168002 | ||
Context | iHOP: POLR2G | |
cancer metabolism search in PubMed: POLR2G | ||
UCL Cancer Institute: POLR2G | ||
Assigned class in ccmGDB | B - This gene belongs to cancer gene. |
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Phenotypic Information for POLR2G(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: POLR2G |
Familial Cancer Database: POLR2G |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_PURINE_METABOLISM KEGG_PYRIMIDINE_METABOLISM |
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OMIM | 602013; gene. |
Orphanet | |
Disease | KEGG Disease: POLR2G |
MedGen: POLR2G (Human Medical Genetics with Condition) | |
ClinVar: POLR2G | |
Phenotype | MGI: POLR2G (International Mouse Phenotyping Consortium) |
PhenomicDB: POLR2G |
Mutations for POLR2G |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows POLR2G related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
CB048938 | SMAP1 | 32 | 58 | 6 | 71428519 | 71428545 | POLR2G | 54 | 454 | 11 | 62532833 | 62534182 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=9) | (# total SNVs=2) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr11:62532690-62532690 | p.F107I | 1 |
chr11:62532822-62532822 | p.S115L | 1 |
chr11:62533155-62533155 | p.R144C | 1 |
chr11:62533156-62533156 | p.R144H | 1 |
chr11:62533177-62533177 | p.R151P | 1 |
chr11:62529276-62529276 | p.E8* | 1 |
chr11:62533187-62533187 | p.K154K | 1 |
chr11:62529353-62529353 | p.E33E | 1 |
chr11:62533739-62533739 | p.D166N | 1 |
chr11:62529367-62529367 | p.C38F | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 1 |   |   |   |   | 1 |   |   |   |   | 2 |   |   |   |   | 1 | 1 |   |   |
# mutation |   | 1 |   |   |   |   | 1 |   |   |   |   | 3 |   |   |   |   | 1 | 1 |   |   |
nonsynonymous SNV |   |   |   |   |   |   | 1 |   |   |   |   | 2 |   |   |   |   |   | 1 |   |   |
synonymous SNV |   | 1 |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   | 1 |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr11:62532822 | p.S115L | 2 |
chr11:62532699 | p.D52N | 1 |
chr11:62532814 | p.G55C | 1 |
chr11:62533156 | p.R110R | 1 |
chr11:62533187 | p.S112S | 1 |
chr11:62530370 | p.R144H | 1 |
chr11:62530379 | p.K154K | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for POLR2G |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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B3GAT3,BANF1,BSCL2,TMEM258,LBHD1___C11orf98,UQCC3,CFL1, COX8A,FIBP,OTUB1,POLR2G,PPP1R14B,SDHAF2,SSSCA1, STX5,TIMM10,TMEM179B,TMEM223,TRMT112,TTC9C,WDR74 | APOA1BP,BUD31,C17orf49,CLTA,JTB,KDELR1,LSM2, MRPL17,MRPS21,NSMCE1,PFDN5,PHF5A,POLR2G,PPIA, SEC61B,SNRPF,TMEM179B,TMEM223,UBE2I,UFC1,YIPF3 |
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ARL2,ATP5L,BANF1,TMEM258,C11orf31,LAMTOR1,C11orf73, COA4,EMG1,FAU,MRPL11,MRPL48,MRPL49,MRPS23, POLR2G,PPP1CA,SDHAF2,TIMM8B,TMEM126A,TMEM223,TRMT112 | ADSL,ELP6,TMEM261,COPS3,DAP3,GEMIN6,HAUS1, HAX1,LSM2,MRPL51,NAA20,NDUFA4,NHP2,POLE3, POLR2G,PSMD10,SIVA1,SNRPC,SNRPD2,TOMM6,ZNF511 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for POLR2G |
There's no related Drug. |
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Cross referenced IDs for POLR2G |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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