The screen analysis calculates the SNP Activity Difference (SAD) and relative log fold change of odds (log-odds) difference between two alleles across all chromatin features for a number of variants (up to 3000 per job). It is mainly used for a preliminary screen, which can aid to discover potential regulatory functional variants, e.g., ranking the query variants based on their SAD or log-odds difference. According to the functional categories and completeness, we constructed two separate models (see below): (a) DNA accessibility profiles, histone mark and transcription factor-CTCF binding profiles and (b) Transcription factors profiles (excluding CTCF).
NOTE: To run screen analysis, it will take ~5 seconds per variant. For jobs with more than 1000 variants, it may take hours to finish. Please input an email address and keep record of the job identifier/ID to retrieve the results later. For each job, we accept a maximum of 3000 variants. If you have more than 3000 variants, please split into multiple jobs and upload separately.