DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
APAAPVPPR
Uniprot ID:
Q5VV17
Source protein:
OTU domain-containing protein 1
Source gene:
OTUD1
Class:
DEG_SIAH_1
Location:
152:160
E3 ligase:
SIAH1,SIAH2,SIAH3
DEGRON score:
0.9902
ASA_SCORE:
85.6111
COIL:
0.961
CONS_SCORE:
0.4964
DSS_SCORE:
0.3812
HELIX:
0.0192
FCONS_SCORE:
0.9805
RIG_SCORE:
0.6607
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with OTUD1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of APAAPVPPR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5VV17
OTU domain-containing protein 1
DEG_SIAH_1
152:160
APAAPVPPR
SIAH1,SIAH2,SIAH3
0.9902
More...