DegronMD

Uniprot ID: Q96EL1

Source protein: PAK4-inhibitor INKA1

Source gene: INKA1

Class: DEG_SIAH_1

Location: 140:148

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9913

ASA_SCORE: 81.8222

COIL: 0.9283

CONS_SCORE: 0.4256

DSS_SCORE: 0.5964

HELIX: 0.021

FCONS_SCORE: 0.6356

RIG_SCORE: 0.5826

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P146L	SIDM00013	Melanoma	GDSC	APVASVPPV	DEG_SIAH_1	0.6471
p.V131A	SIDM00118	Colorectal Carcinoma	GDSC	APVASVPPV	DEG_SIAH_1	0.0833
p.V131A	HCC2998	large_intestine	COSMIC	APVASVPPV	DEG_SIAH_1	0.0833
p.S155F	SIDM00153	T-Lymphoblastic Leukemia	GDSC	APVASVPPV	DEG_SIAH_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96EL1	PAK4-inhibitor INKA1	DEG_SIAH_1	140:148	APVASVPPV	SIAH1,SIAH2,SIAH3	0.9913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons