DegronMD

Uniprot ID: P54646

Source protein: 5'-AMP-activated protein kinase catalytic subunit alpha-2

Source gene: PRKAA2

Class: DEG_APCC_DBOX_1

Location: 380:388

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8247

ASA_SCORE: 74.3111

COIL: 0.7333

CONS_SCORE: 0.2347

DSS_SCORE: 0.5158

HELIX: 0.2211

FCONS_SCORE: 0.9797

RIG_SCORE: 0.7391

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T389M	TCGA-06-5416	GBM	TCGA	ARCPLDALN	DEG_APCC_DBOX_1	0.3056
p.T389M	DO10880	GBM	ICGC	ARCPLDALN	DEG_APCC_DBOX_1	0.3056
p.T389M	SIDM01293	Colorectal Carcinoma	GDSC	ARCPLDALN	DEG_APCC_DBOX_1	0.3056
p.S377I	TCGA-AP-A051	UCEC	TCGA	ARCPLDALN	DEG_APCC_DBOX_1	0.6944
p.S377I	DO42673	UCEC	ICGC	ARCPLDALN	DEG_APCC_DBOX_1	0.6944
p.S377N	TCGA-DA-A1I1	SKCM	TCGA	ARCPLDALN	DEG_APCC_DBOX_1	0.6944
p.S377N	DO37966	SKCM	ICGC	ARCPLDALN	DEG_APCC_DBOX_1	0.6944
p.P378H	TCGA-FS-A1ZP	SKCM	TCGA	ARCPLDALN	DEG_APCC_DBOX_1	0.2778
p.P378H	DO37703	SKCM	ICGC	ARCPLDALN	DEG_APCC_DBOX_1	0.2778
p.P392L	TCGA-GN-A4U8	SKCM	TCGA	ARCPLDALN	DEG_APCC_DBOX_1	0.2222
p.P392L	DO47320	SKCM	ICGC	ARCPLDALN	DEG_APCC_DBOX_1	0.2222
p.K391R	TCGA-RD-A8MW	STAD	TCGA	ARCPLDALN	DEG_APCC_DBOX_1	0.6944
p.K391R	DO50134	STAD	ICGC	ARCPLDALN	DEG_APCC_DBOX_1	0.6944
p.S394F	DO222908	MELA	ICGC	ARCPLDALN	DEG_APCC_DBOX_1	0.1667
p.P371T	SIDM00885	Breast Carcinoma	GDSC	ARCPLDALN	DEG_APCC_DBOX_1	0.0833
p.P371T	ACH-000111	Breast Cancer	CCLE	ARCPLDALN	DEG_APCC_DBOX_1	0.0833
p.P371T	HCC1187	breast	COSMIC	ARCPLDALN	DEG_APCC_DBOX_1	0.0833
p.V397M	SIDM00282	Colorectal Carcinoma	GDSC	ARCPLDALN	DEG_APCC_DBOX_1	0.0833
p.V397M	ACH-000998	Colon/Colorectal Cancer	CCLE	ARCPLDALN	DEG_APCC_DBOX_1	0.0833
p.V397M	CW-2	large_intestine	COSMIC	ARCPLDALN	DEG_APCC_DBOX_1	0.0833
p.P378L	ACH-002396	Bone Cancer	CCLE	ARCPLDALN	DEG_APCC_DBOX_1	0.2778
p.P378L	Sarc9371	bone	COSMIC	ARCPLDALN	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54646	5'-AMP-activated protein kinase catalytic subunit alpha-2	DEG_APCC_DBOX_1	380:388	ARCPLDALN	APC,CDC20,FZR1	0.8247	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons