DegronMD

Uniprot ID: Q8IUH4

Source protein: Palmitoyltransferase ZDHHC13

Source gene: ZDHHC13

Class: DEG_APCC_DBOX_1

Location: 38:46

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8236

ASA_SCORE: 83

COIL: 0.9113

CONS_SCORE: 0.2799

DSS_SCORE: 0.2952

HELIX: 0.0498

FCONS_SCORE: 0.8595

RIG_SCORE: 0.8144

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L35P	TCGA-HU-A4GH	STAD	TCGA	AREALPLIE	DEG_APCC_DBOX_1	0.25
p.L35P	DO47743	STAD	ICGC	AREALPLIE	DEG_APCC_DBOX_1	0.25
p.V54F	DO229034	LICA	ICGC	AREALPLIE	DEG_APCC_DBOX_1	0.1111
p.V54F	DO229035	LICA	ICGC	AREALPLIE	DEG_APCC_DBOX_1	0.1111
p.A56V	SIDM00789	Colorectal Carcinoma	GDSC	AREALPLIE	DEG_APCC_DBOX_1	0.0556
p.A56V	ACH-000997	Colon/Colorectal Cancer	CCLE	AREALPLIE	DEG_APCC_DBOX_1	0.0556
p.A56V	ACH-001061	Colon/Colorectal Cancer	CCLE	AREALPLIE	DEG_APCC_DBOX_1	0.0556
p.A56V	HCT-15	large_intestine	COSMIC	AREALPLIE	DEG_APCC_DBOX_1	0.0556
p.A29S	SIDM00217	Colorectal Carcinoma	GDSC	AREALPLIE	DEG_APCC_DBOX_1	0.0833
p.A29S	ACH-000999	Colon/Colorectal Cancer	CCLE	AREALPLIE	DEG_APCC_DBOX_1	0.0833
p.A29S	SNU-1040	large_intestine	COSMIC	AREALPLIE	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUH4	Palmitoyltransferase ZDHHC13	DEG_APCC_DBOX_1	38:46	AREALPLIE	APC,CDC20,FZR1	0.8236	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons