DegronMD

Uniprot ID: Q8NF86

Source protein: Serine protease 33

Source gene: PRSS33

Class: DEG_APCC_DBOX_1

Location: 123:131

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7059

ASA_SCORE: 25.8667

COIL: 0.3072

CONS_SCORE: 0.6672

DSS_SCORE: 0.3668

HELIX: 0.0313

FCONS_SCORE: 1.3453

RIG_SCORE: 0.7924

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R124L	DO26806	LUSC	ICGC	ARGDLALLQ	DEG_APCC_DBOX_1	0.8428
p.R141G	ACH-000963	Colon/Colorectal Cancer	CCLE	ARGDLALLQ	DEG_APCC_DBOX_1	0.0556
p.A123T	ACH-001001	Bone Cancer	CCLE	ARGDLALLQ	DEG_APCC_DBOX_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NF86	Serine protease 33	DEG_APCC_DBOX_1	123:131	ARGDLALLQ	APC,CDC20,FZR1	0.7059	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons