DegronMD

Uniprot ID: Q3B7T1

Source protein: Erythroid differentiation-related factor 1

Source gene: EDRF1

Class: DEG_APCC_DBOX_1

Location: 18:26

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9287

ASA_SCORE: 73.3556

COIL: 0.6873

CONS_SCORE: 0.3002

DSS_SCORE: 0.5685

HELIX: 0.215

FCONS_SCORE: 1.0316

RIG_SCORE: 0.664

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S34F	TCGA-C5-A7X5	CESC	TCGA	ARGGLSLLS	DEG_APCC_DBOX_1	0.1111
p.E10Q	TCGA-CV-A45O	HNSC	TCGA	ARGGLSLLS	DEG_APCC_DBOX_1	0.1111
p.E10Q	TCGA-LA-A446	LUSC	TCGA	ARGGLSLLS	DEG_APCC_DBOX_1	0.1111
p.G15V	TCGA-D9-A148	SKCM	TCGA	ARGGLSLLS	DEG_APCC_DBOX_1	0.25
p.Q27L	TCGA-EL-A3CU	THCA	TCGA	ARGGLSLLS	DEG_APCC_DBOX_1	0.3056
p.A14V	TCGA-EO-A3KX	UCEC	TCGA	ARGGLSLLS	DEG_APCC_DBOX_1	0.2222
p.A18T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ARGGLSLLS	DEG_APCC_DBOX_1	0.6028
p.A18T	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	ARGGLSLLS	DEG_APCC_DBOX_1	0.6028
p.A16P	SIDM00336	Melanoma	GDSC	ARGGLSLLS	DEG_APCC_DBOX_1	0.2778
p.R19Q	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	ARGGLSLLS	DEG_APCC_DBOX_1	0.7329
p.R19Q	SIDM00844	Burkitt's Lymphoma	GDSC	ARGGLSLLS	DEG_APCC_DBOX_1	0.7329
p.R19Q	SIDM00760	Small Cell Lung Carcinoma	GDSC	ARGGLSLLS	DEG_APCC_DBOX_1	0.7329
p.G20V	SIDM00528	Breast Carcinoma	GDSC	ARGGLSLLS	DEG_APCC_DBOX_1	0.6421
p.G20V	MDA-MB-361	breast	COSMIC	ARGGLSLLS	DEG_APCC_DBOX_1	0.6421

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3B7T1	Erythroid differentiation-related factor 1	DEG_APCC_DBOX_1	18:26	ARGGLSLLS	APC,CDC20,FZR1	0.9287	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons