DegronMD

Uniprot ID: Q9UD57

Source protein: NK1 transcription factor-related protein 2

Source gene: NKX1-2

Class: DEG_APCC_DBOX_1

Location: 46:54

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.915

ASA_SCORE: 88.2556

COIL: 0.3591

CONS_SCORE: 0.3558

DSS_SCORE: 0.5907

HELIX: 0.6388

FCONS_SCORE: 1.4234

RIG_SCORE: 0.6955

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A55V	TCGA-2W-A8YY	CESC	TCGA	ARKSLAEVE	DEG_APCC_DBOX_1	0.3056
p.A55V	DO223732	CESC	ICGC	ARKSLAEVE	DEG_APCC_DBOX_1	0.3056
p.S60N	TCGA-D1-A1NY	UCEC	TCGA	ARKSLAEVE	DEG_APCC_DBOX_1	0.1667
p.S60N	DO42512	UCEC	ICGC	ARKSLAEVE	DEG_APCC_DBOX_1	0.1667
p.G56V	DO233650	GACA	ICGC	ARKSLAEVE	DEG_APCC_DBOX_1	0.2778
p.A55E	DO228978	LICA	ICGC	ARKSLAEVE	DEG_APCC_DBOX_1	0.3056
p.R47S	ACH-000681	Lung Cancer	CCLE	ARKSLAEVE	DEG_APCC_DBOX_1	0.7427
p.D63H	ACH-001618	Leukemia	CCLE	ARKSLAEVE	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UD57	NK1 transcription factor-related protein 2	DEG_APCC_DBOX_1	46:54	ARKSLAEVE	APC,CDC20,FZR1	0.915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons