DegronMD

Uniprot ID: P40259

Source protein: B-cell antigen receptor complex-associated protein beta chain

Source gene: CD79B

Class: DEG_APCC_DBOX_1

Location: 2:10

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6033

ASA_SCORE: 78.4667

COIL: 0.8304

CONS_SCORE: 0.5192

DSS_SCORE: 0.3193

HELIX: 0.104

FCONS_SCORE: 0.9428

RIG_SCORE: 0.7617

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A16V	TCGA-FI-A2D5	UCEC	TCGA	ARLALSPVP	DEG_APCC_DBOX_1	0.1667
p.A16V	DO41331	UCEC	ICGC	ARLALSPVP	DEG_APCC_DBOX_1	0.1667
p.R3K	TCGA-UT-A88D	MESO	TCGA	ARLALSPVP	DEG_APCC_DBOX_1	0.7237
p.L19Q	DO228301	LICA	ICGC	ARLALSPVP	DEG_APCC_DBOX_1	0.0833
p.S11R	DO229027	LICA	ICGC	ARLALSPVP	DEG_APCC_DBOX_1	0.3056
p.S11N	SIDM02015	Colorectal Carcinoma	GDSC	ARLALSPVP	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40259	B-cell antigen receptor complex-associated protein beta chain	DEG_APCC_DBOX_1	2:10	ARLALSPVP	APC,CDC20,FZR1	0.6033	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons