DegronMD

Uniprot ID: Q12769

Source protein: Nuclear pore complex protein Nup160

Source gene: NUP160

Class: DEG_APCC_DBOX_1

Location: 19:27

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7841

ASA_SCORE: 54.0556

COIL: 0.6311

CONS_SCORE: 0.1621

DSS_SCORE: 0.3865

HELIX: 0.0564

FCONS_SCORE: 1.1382

RIG_SCORE: 0.7789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A17T	TCGA-A5-A2K5	UCEC	TCGA	ARPCLCSVG	DEG_APCC_DBOX_1	0.2778
p.A17T	TCGA-FI-A2D5	UCEC	TCGA	ARPCLCSVG	DEG_APCC_DBOX_1	0.2778
p.A17T	DO41331	UCEC	ICGC	ARPCLCSVG	DEG_APCC_DBOX_1	0.2778
p.A17T	DO41379	UCEC	ICGC	ARPCLCSVG	DEG_APCC_DBOX_1	0.2778
p.A36T	TCGA-OR-A5KX	ACC	TCGA	ARPCLCSVG	DEG_APCC_DBOX_1	0.0833
p.V15M	TCGA-P4-AAVL	KIRP	TCGA	ARPCLCSVG	DEG_APCC_DBOX_1	0.2222
p.V15M	DO219694	KIRP	ICGC	ARPCLCSVG	DEG_APCC_DBOX_1	0.2222
p.D31G	DO229036	LICA	ICGC	ARPCLCSVG	DEG_APCC_DBOX_1	0.2222
p.S25F	DO222647	MELA	ICGC	ARPCLCSVG	DEG_APCC_DBOX_1	0.6871
p.E14K	DO232224	PBCA	ICGC	ARPCLCSVG	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12769	Nuclear pore complex protein Nup160	DEG_APCC_DBOX_1	19:27	ARPCLCSVG	APC,CDC20,FZR1	0.7841	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons