DegronMD

Uniprot ID: O15055

Source protein: Period circadian protein homolog 2

Source gene: PER2

Class: DEG_APCC_DBOX_1

Location: 819:827

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9915

ASA_SCORE: 86.4333

COIL: 0.9268

CONS_SCORE: 0.4611

DSS_SCORE: 0.5652

HELIX: 0.0378

FCONS_SCORE: 1.1087

RIG_SCORE: 0.6758

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P822S	TCGA-43-A56V	LUSC	TCGA	ARPPLVGLN	DEG_APCC_DBOX_1	0.5641
p.P822S	TCGA-EE-A2MC	SKCM	TCGA	ARPPLVGLN	DEG_APCC_DBOX_1	0.5641
p.P822S	DO45535	LUSC	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.5641
p.P822S	DO37559	SKCM	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.5641
p.P833L	TCGA-85-7950	LUSC	TCGA	ARPPLVGLN	DEG_APCC_DBOX_1	0.1667
p.P833L	DO26878	LUSC	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.1667
p.S813Y	TCGA-AP-A1DV	UCEC	TCGA	ARPPLVGLN	DEG_APCC_DBOX_1	0.1667
p.S813Y	DO43186	UCEC	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.1667
p.A819T	TCGA-BR-4361	STAD	TCGA	ARPPLVGLN	DEG_APCC_DBOX_1	0.6028
p.A819T	TCGA-VQ-AA6B	STAD	TCGA	ARPPLVGLN	DEG_APCC_DBOX_1	0.6028
p.A819T	DO51800	STAD	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.6028
p.A819T	DO38887	STAD	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.6028
p.P822L	TCGA-EE-A2MC	SKCM	TCGA	ARPPLVGLN	DEG_APCC_DBOX_1	0.6471
p.P822L	DO37559	SKCM	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.6471
p.V817M	TCGA-VQ-A8P2	STAD	TCGA	ARPPLVGLN	DEG_APCC_DBOX_1	0.2778
p.V817M	DO51761	STAD	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.2778
p.V817M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.2778
p.V817M	SIDM00333	Endometrial Carcinoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.2778
p.V817M	ACH-000988	Endometrial/Uterine Cancer	CCLE	ARPPLVGLN	DEG_APCC_DBOX_1	0.2778
p.V817M	ACH-002256	Leukemia	CCLE	ARPPLVGLN	DEG_APCC_DBOX_1	0.2778
p.V817M	MFE-319	endometrium	COSMIC	ARPPLVGLN	DEG_APCC_DBOX_1	0.2778
p.V817M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ARPPLVGLN	DEG_APCC_DBOX_1	0.2778
p.N827K	DO50407	ESAD	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.5806
p.R820W	DO223004	ESCA	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.8634
p.P822Q	DO222363	MELA	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.5924
p.S818F	DO222837	MELA	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.S818F	SIDM00007	Other Solid Cancers	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.S818F	ACH-001550	Skin Cancer	CCLE	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.S818F	MCC13	skin	COSMIC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.G825C	DO50727	ORCA	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.6489
p.W831R	DO229245	THCA	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.2222
p.A828T	SIDM01265	Plasma Cell Myeloma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.A828T	SIDM00845	Burkitt's Lymphoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.A828T	SIDM01090	Colorectal Carcinoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.A828T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.A828T	SIDM00967	Ovarian Carcinoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.A828T	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.A828T	SIDM00807	Bladder Carcinoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.A828T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.A828T	SIDM01059	Melanoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.A828T	SIDM00808	Burkitt's Lymphoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.A828T	SIDM00628	Breast Carcinoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.A828T	SIDM01254	Burkitt's Lymphoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.A828T	SIDM01525	Acute Myeloid Leukemia	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.G812E	SIDM00319	Melanoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.1389
p.G812E	ACH-001704	Skin Cancer	CCLE	ARPPLVGLN	DEG_APCC_DBOX_1	0.1389
p.G812E	VMRC-MELG	skin	COSMIC	ARPPLVGLN	DEG_APCC_DBOX_1	0.1389
p.L823V	SIDM00675	Breast Carcinoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.6765
p.L823V	ACH-000276	Breast Cancer	CCLE	ARPPLVGLN	DEG_APCC_DBOX_1	0.6765
p.L823V	HCC38	breast	COSMIC	ARPPLVGLN	DEG_APCC_DBOX_1	0.6765
p.G812R	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.1389
p.G812R	COR-L32	lung	COSMIC	ARPPLVGLN	DEG_APCC_DBOX_1	0.1389
p.G815W	ACH-001367	Neuroblastoma	CCLE	ARPPLVGLN	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARPPLVGLN

Degron related mutations and impact score

Drug responses associated with PER2 mutations

All proteins holding degron of ARPPLVGLN

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15055	Period circadian protein homolog 2	DEG_APCC_DBOX_1	819:827	ARPPLVGLN	APC,CDC20,FZR1	0.9915	More...