DegronMD

Uniprot ID: O15055

Source protein: Period circadian protein homolog 2

Source gene: PER2

Class: DEG_APCC_DBOX_1

Location: 819:827

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9915

ASA_SCORE: 86.4333

COIL: 0.9268

CONS_SCORE: 0.4611

DSS_SCORE: 0.5652

HELIX: 0.0378

FCONS_SCORE: 1.1087

RIG_SCORE: 0.6758

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R820W	DO223004	ESCA	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.8634
p.L823V	SIDM00675	Breast Carcinoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.6765
p.L823V	ACH-000276	Breast Cancer	CCLE	ARPPLVGLN	DEG_APCC_DBOX_1	0.6765
p.L823V	HCC38	breast	COSMIC	ARPPLVGLN	DEG_APCC_DBOX_1	0.6765
p.G825C	DO50727	ORCA	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.6489
p.P822L	TCGA-EE-A2MC	SKCM	TCGA	ARPPLVGLN	DEG_APCC_DBOX_1	0.6471
p.P822L	DO37559	SKCM	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.6471
p.A819T	TCGA-BR-4361	STAD	TCGA	ARPPLVGLN	DEG_APCC_DBOX_1	0.6028
p.A819T	TCGA-VQ-AA6B	STAD	TCGA	ARPPLVGLN	DEG_APCC_DBOX_1	0.6028
p.A819T	DO51800	STAD	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.6028
p.A819T	DO38887	STAD	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.6028
p.P822Q	DO222363	MELA	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.5924
p.N827K	DO50407	ESAD	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.5806
p.P822S	TCGA-43-A56V	LUSC	TCGA	ARPPLVGLN	DEG_APCC_DBOX_1	0.5641
p.P822S	TCGA-EE-A2MC	SKCM	TCGA	ARPPLVGLN	DEG_APCC_DBOX_1	0.5641
p.P822S	DO45535	LUSC	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.5641
p.P822S	DO37559	SKCM	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.5641
p.S818F	DO222837	MELA	ICGC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.S818F	SIDM00007	Other Solid Cancers	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.S818F	ACH-001550	Skin Cancer	CCLE	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.S818F	MCC13	skin	COSMIC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.A828T	SIDM01265	Plasma Cell Myeloma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.A828T	SIDM00845	Burkitt's Lymphoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.A828T	SIDM01090	Colorectal Carcinoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056
p.A828T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ARPPLVGLN	DEG_APCC_DBOX_1	0.3056

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Drug responses associated with PER2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of ARPPLVGLN

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15055	Period circadian protein homolog 2	DEG_APCC_DBOX_1	819:827	ARPPLVGLN	APC,CDC20,FZR1	0.9915	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARPPLVGLN

Degron related mutations and impact score

Drug responses associated with PER2 mutations

All proteins holding degron of ARPPLVGLN