DegronMD

Uniprot ID: P49407

Source protein: Beta-arrestin-1

Source gene: ARRB1

Class: DEG_APCC_DBOX_1

Location: 392:400

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9796

ASA_SCORE: 98.7222

COIL: 0.5581

CONS_SCORE: 0.4943

DSS_SCORE: 0.5665

HELIX: 0.4206

FCONS_SCORE: 1.1741

RIG_SCORE: 0.7381

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D384V	TCGA-51-4080	LUSC	TCGA	ARQRLKGMK	DEG_APCC_DBOX_1	0.1111
p.K403N	TCGA-AP-A059	UCEC	TCGA	ARQRLKGMK	DEG_APCC_DBOX_1	0.3611
p.K403N	DO41361	UCEC	ICGC	ARQRLKGMK	DEG_APCC_DBOX_1	0.3611
p.D385N	TCGA-FU-A3HZ	CESC	TCGA	ARQRLKGMK	DEG_APCC_DBOX_1	0.1389
p.D385N	DO6308	CESC	ICGC	ARQRLKGMK	DEG_APCC_DBOX_1	0.1389
p.R393C	TCGA-H4-A2HQ	BLCA	TCGA	ARQRLKGMK	DEG_APCC_DBOX_1	0.8301
p.R393C	DO522	BLCA	ICGC	ARQRLKGMK	DEG_APCC_DBOX_1	0.8301
p.G403S	DO222916	BTCA	ICGC	ARQRLKGMK	DEG_APCC_DBOX_1	0.3611
p.M399V	DO228941	LICA	ICGC	ARQRLKGMK	DEG_APCC_DBOX_1	0.6097
p.M399V	SIDM01197	Colorectal Carcinoma	GDSC	ARQRLKGMK	DEG_APCC_DBOX_1	0.6097
p.M399V	SIDM00365	Small Cell Lung Carcinoma	GDSC	ARQRLKGMK	DEG_APCC_DBOX_1	0.6097
p.M399V	SIDM01695	Acute Myeloid Leukemia	GDSC	ARQRLKGMK	DEG_APCC_DBOX_1	0.6097
p.M399V	SIDM01691	Chronic Myelogenous Leukemia	GDSC	ARQRLKGMK	DEG_APCC_DBOX_1	0.6097
p.D394N	DO34112	PACA	ICGC	ARQRLKGMK	DEG_APCC_DBOX_1	0.6932
p.E404D	SIDM00845	Burkitt's Lymphoma	GDSC	ARQRLKGMK	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49407	Beta-arrestin-1	DEG_APCC_DBOX_1	392:400	ARQRLKGMK	APC,CDC20,FZR1	0.9796	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons