DegronMD

Uniprot ID: O60755

Source protein: Galanin receptor type 3

Source gene: GALR3

Class: DEG_APCC_DBOX_1

Location: 316:324

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9844

ASA_SCORE: 145.0222

COIL: 0.7289

CONS_SCORE: 0.5261

DSS_SCORE: 0.5968

HELIX: 0.2093

FCONS_SCORE: 1.2086

RIG_SCORE: 0.7083

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V323I	DO222955	BTCA	ICGC	ARRALRRVR	DEG_APCC_DBOX_1	0.5965
p.V323I	ACH-002512	Skin Cancer	CCLE	ARRALRRVR	DEG_APCC_DBOX_1	0.5965
p.R310C	DO233693	GACA	ICGC	ARRALRRVR	DEG_APCC_DBOX_1	0.1667
p.R318C	DO231284	PACA	ICGC	ARRALRRVR	DEG_APCC_DBOX_1	0.719
p.C308R	SIDM00882	Breast Carcinoma	GDSC	ARRALRRVR	DEG_APCC_DBOX_1	0.1111
p.S327F	ACH-000221	Liver Cancer	CCLE	ARRALRRVR	DEG_APCC_DBOX_1	0.25
p.A326T	ACH-000948	Gastric Cancer	CCLE	ARRALRRVR	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60755	Galanin receptor type 3	DEG_APCC_DBOX_1	316:324	ARRALRRVR	APC,CDC20,FZR1	0.9844	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons