DegronMD

Uniprot ID: P39019

Source protein: 40S ribosomal protein S19

Source gene: RPS19

Class: DEG_APCC_DBOX_1

Location: 100:108

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.689

ASA_SCORE: 54.9667

COIL: 0.1813

CONS_SCORE: 0.7104

DSS_SCORE: 0.4277

HELIX: 0.7999

FCONS_SCORE: 1.2277

RIG_SCORE: 0.7857

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R101H	TCGA-CN-4728	HNSC	TCGA	ARRVLQALE	DEG_APCC_DBOX_1	0.8244
p.R101S	TCGA-D3-A2JP	SKCM	TCGA	ARRVLQALE	DEG_APCC_DBOX_1	0.7427
p.R102L	TCGA-D3-A3C7	SKCM	TCGA	ARRVLQALE	DEG_APCC_DBOX_1	0.7316
p.R102L	TCGA-VS-A94Z	CESC	TCGA	ARRVLQALE	DEG_APCC_DBOX_1	0.7316
p.R101L	SIDM00461	Acute Myeloid Leukemia	GDSC	ARRVLQALE	DEG_APCC_DBOX_1	0.8428
p.S90G	ACH-000710	Lung Cancer	CCLE	ARRVLQALE	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P39019	40S ribosomal protein S19	DEG_APCC_DBOX_1	100:108	ARRVLQALE	APC,CDC20,FZR1	0.689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons