DegronMD

Uniprot ID: Q9HBW1

Source protein: Leucine-rich repeat-containing protein 4

Source gene: LRRC4

Class: DEG_SPOP_SBC_1

Location: 486:490

E3 ligase: SPOP

DEGRON score: 0.9989

ASA_SCORE: 77.54

COIL: 0.6966

CONS_SCORE: 0.4064

DSS_SCORE: 0.4306

HELIX: 0.0368

FCONS_SCORE: 1.021

RIG_SCORE: 0.7807

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T492K	TCGA-44-8117	LUAD	TCGA	AYTTS	DEG_SPOP_SBC_1	0.2778
p.T492K	DO24028	LUAD	ICGC	AYTTS	DEG_SPOP_SBC_1	0.2778
p.Q484H	TCGA-A5-A1OF	UCEC	TCGA	AYTTS	DEG_SPOP_SBC_1	0.2778
p.Q484H	DO42568	UCEC	ICGC	AYTTS	DEG_SPOP_SBC_1	0.2778
p.P485S	TCGA-AP-A059	UCEC	TCGA	AYTTS	DEG_SPOP_SBC_1	0.3056
p.P485S	DO41361	UCEC	ICGC	AYTTS	DEG_SPOP_SBC_1	0.3056
p.T489N	DO229032	LICA	ICGC	AYTTS	DEG_SPOP_SBC_1	0.7055
p.Y487H	DO23296	LINC	ICGC	AYTTS	DEG_SPOP_SBC_1	0.6118
p.R499H	DO35484	PACA	ICGC	AYTTS	DEG_SPOP_SBC_1	0.0833
p.Q496H	SIDM00466	Ovarian Carcinoma	GDSC	AYTTS	DEG_SPOP_SBC_1	0.1667
p.Q496H	ACH-000443	Ovarian Cancer	CCLE	AYTTS	DEG_SPOP_SBC_1	0.1667
p.Q496H	OVKATE	ovary	COSMIC	AYTTS	DEG_SPOP_SBC_1	0.1667
p.T489I	SIDM00199	Chondrosarcoma	GDSC	AYTTS	DEG_SPOP_SBC_1	0.7078
p.T489I	ACH-002099	Bone Cancer	CCLE	AYTTS	DEG_SPOP_SBC_1	0.7078
p.T489I	CS1	bone	COSMIC	AYTTS	DEG_SPOP_SBC_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBW1	Leucine-rich repeat-containing protein 4	DEG_SPOP_SBC_1	486:490	AYTTS	SPOP	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons