DegronMD

Uniprot ID: Q9BXR6

Source protein: Complement factor H-related protein 5

Source gene: CFHR5

Class: DEG_APCC_KENBOX_2

Location: 417:421

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.699

ASA_SCORE: 78.82

COIL: 0.7622

CONS_SCORE: 1

DSS_SCORE: 0.1622

HELIX: 0.006

FCONS_SCORE: 1.0517

RIG_SCORE: 0.9085

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C417F	TCGA-55-1592	LUAD	TCGA	CKENY	DEG_APCC_KENBOX_2	0.5996
p.A414V	TCGA-75-7027	LUAD	TCGA	CKENY	DEG_APCC_KENBOX_2	0.25
p.A414V	TCGA-BR-4370	STAD	TCGA	CKENY	DEG_APCC_KENBOX_2	0.25
p.C431F	TCGA-85-8071	LUSC	TCGA	CKENY	DEG_APCC_KENBOX_2	0.0556
p.E428Q	TCGA-AC-A23H	BRCA	TCGA	CKENY	DEG_APCC_KENBOX_2	0.1389
p.L416P	TCGA-AJ-A5DW	UCEC	TCGA	CKENY	DEG_APCC_KENBOX_2	0.3056
p.C417S	TCGA-CV-A45Z	HNSC	TCGA	CKENY	DEG_APCC_KENBOX_2	0.643
p.E428K	TCGA-D9-A6EC	SKCM	TCGA	CKENY	DEG_APCC_KENBOX_2	0.1389
p.P424S	TCGA-DA-A95Z	SKCM	TCGA	CKENY	DEG_APCC_KENBOX_2	0.25
p.I419M	DO227987	COCA	ICGC	CKENY	DEG_APCC_KENBOX_2	0.7618
p.K408E	DO234257	ESAD	ICGC	CKENY	DEG_APCC_KENBOX_2	0.0833
p.C413F	DO233738	GACA	ICGC	CKENY	DEG_APCC_KENBOX_2	0.2222
p.P420T	DO27136	LUSC	ICGC	CKENY	DEG_APCC_KENBOX_2	0.7031
p.R409G	DO228236	MALY	ICGC	CKENY	DEG_APCC_KENBOX_2	0.1111
p.R409K	DO229542	UTCA	ICGC	CKENY	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXR6	Complement factor H-related protein 5	DEG_APCC_KENBOX_2	417:421	CKENY	APC,CDC20,FZR1	0.699	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons