DegronMD

Uniprot ID: Q9Y4B6

Source protein: DDB1- and CUL4-associated factor 1

Source gene: DCAF1

Class: DEG_APCC_DBOX_1

Location: 106:114

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5314

ASA_SCORE: 20.2889

COIL: 0.1676

CONS_SCORE: 0.5467

DSS_SCORE: 0.0822

HELIX: 0.8199

FCONS_SCORE: 1.2283

RIG_SCORE: 0.9084

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G115V	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	CRLLLDIMP	DEG_APCC_DBOX_1	0.3056
p.G115V	NCI-H2291	lung	COSMIC	CRLLLDIMP	DEG_APCC_DBOX_1	0.3056
p.A105T	SIDM01088	Endometrial Carcinoma	GDSC	CRLLLDIMP	DEG_APCC_DBOX_1	0.3056
p.A105T	RL95-2	endometrium	COSMIC	CRLLLDIMP	DEG_APCC_DBOX_1	0.3056
p.G114V	NCI-H2291	lung	COSMIC	CRLLLDIMP	DEG_APCC_DBOX_1	0.7532
p.A104T	RL95-2	endometrium	COSMIC	CRLLLDIMP	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4B6	DDB1- and CUL4-associated factor 1	DEG_APCC_DBOX_1	106:114	CRLLLDIMP	APC,CDC20,FZR1	0.5314	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons