DegronMD

Uniprot ID: Q5JPB2

Source protein: Zinc finger protein 831

Source gene: ZNF831

Class: DEG_APCC_DBOX_1

Location: 1371:1379

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7687

ASA_SCORE: 91.7667

COIL: 0.8617

CONS_SCORE: 0.3675

DSS_SCORE: 0.4592

HELIX: 0.1089

FCONS_SCORE: 0.8355

RIG_SCORE: 0.7549

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1373H	TCGA-AA-A00N	COAD	TCGA	CRQTLGTLS	DEG_APCC_DBOX_1	0.647
p.Q1373H	DO9876	COAD	ICGC	CRQTLGTLS	DEG_APCC_DBOX_1	0.647
p.I1386M	TCGA-AX-A06F	UCEC	TCGA	CRQTLGTLS	DEG_APCC_DBOX_1	0.1389
p.I1386M	DO41752	UCEC	ICGC	CRQTLGTLS	DEG_APCC_DBOX_1	0.1389
p.R1385T	TCGA-B5-A1N2	UCEC	TCGA	CRQTLGTLS	DEG_APCC_DBOX_1	0.1667
p.R1385T	DO41602	UCEC	ICGC	CRQTLGTLS	DEG_APCC_DBOX_1	0.1667
p.E1364K	TCGA-DA-A95Z	SKCM	TCGA	CRQTLGTLS	DEG_APCC_DBOX_1	0.1389
p.E1364K	DO45237	LIRI	ICGC	CRQTLGTLS	DEG_APCC_DBOX_1	0.1389
p.E1364K	DO220906	MELA	ICGC	CRQTLGTLS	DEG_APCC_DBOX_1	0.1389
p.E1364K	DO219481	SKCM	ICGC	CRQTLGTLS	DEG_APCC_DBOX_1	0.1389
p.E1389K	TCGA-DA-A960	SKCM	TCGA	CRQTLGTLS	DEG_APCC_DBOX_1	0.0556
p.E1389K	TCGA-EE-A3AB	SKCM	TCGA	CRQTLGTLS	DEG_APCC_DBOX_1	0.0556
p.E1389K	DO222670	MELA	ICGC	CRQTLGTLS	DEG_APCC_DBOX_1	0.0556
p.E1389K	DO38057	SKCM	ICGC	CRQTLGTLS	DEG_APCC_DBOX_1	0.0556
p.E1389K	DO219482	SKCM	ICGC	CRQTLGTLS	DEG_APCC_DBOX_1	0.0556
p.D1370E	TCGA-OR-A5KB	ACC	TCGA	CRQTLGTLS	DEG_APCC_DBOX_1	0.3056
p.R1385I	TCGA-QF-A5YS	UCEC	TCGA	CRQTLGTLS	DEG_APCC_DBOX_1	0.1667
p.R1385I	DO52426	UCEC	ICGC	CRQTLGTLS	DEG_APCC_DBOX_1	0.1667
p.S1384L	TCGA-RP-A694	SKCM	TCGA	CRQTLGTLS	DEG_APCC_DBOX_1	0.1944
p.S1384L	DO51269	SKCM	ICGC	CRQTLGTLS	DEG_APCC_DBOX_1	0.1944
p.E1365G	DO233102	GACA	ICGC	CRQTLGTLS	DEG_APCC_DBOX_1	0.1667
p.E1364I	DO220906	MELA	ICGC	CRQTLGTLS	DEG_APCC_DBOX_1	0.1389
p.E1364V	DO220906	MELA	ICGC	CRQTLGTLS	DEG_APCC_DBOX_1	0.1389
p.T1377A	SIDM00969	Ovarian Carcinoma	GDSC	CRQTLGTLS	DEG_APCC_DBOX_1	0.6028
p.T1377A	SIDM00082	Melanoma	GDSC	CRQTLGTLS	DEG_APCC_DBOX_1	0.6028
p.T1377A	SIDM00447	B-Lymphoblastic Leukemia	GDSC	CRQTLGTLS	DEG_APCC_DBOX_1	0.6028
p.T1377A	SIDM00842	Colorectal Carcinoma	GDSC	CRQTLGTLS	DEG_APCC_DBOX_1	0.6028
p.T1377A	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	CRQTLGTLS	DEG_APCC_DBOX_1	0.6028
p.T1377A	SIDM00875	Breast Carcinoma	GDSC	CRQTLGTLS	DEG_APCC_DBOX_1	0.6028
p.T1377A	SIDM00793	Burkitt's Lymphoma	GDSC	CRQTLGTLS	DEG_APCC_DBOX_1	0.6028
p.T1377A	SIDM01664	Prostate Carcinoma	GDSC	CRQTLGTLS	DEG_APCC_DBOX_1	0.6028
p.T1377A	SIDM01590	Breast Carcinoma	GDSC	CRQTLGTLS	DEG_APCC_DBOX_1	0.6028
p.S1383C	SIDM00958	Chronic Myelogenous Leukemia	GDSC	CRQTLGTLS	DEG_APCC_DBOX_1	0.2222
p.S1383C	ACH-000920	Leukemia	CCLE	CRQTLGTLS	DEG_APCC_DBOX_1	0.2222
p.S1383C	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	CRQTLGTLS	DEG_APCC_DBOX_1	0.2222
p.R1388K	SIDM00837	Colorectal Carcinoma	GDSC	CRQTLGTLS	DEG_APCC_DBOX_1	0.0833
p.R1388K	ACH-000958	Colon/Colorectal Cancer	CCLE	CRQTLGTLS	DEG_APCC_DBOX_1	0.0833
p.R1385G	SIDM00515	Melanoma	GDSC	CRQTLGTLS	DEG_APCC_DBOX_1	0.1667
p.R1385G	ACH-000401	Skin Cancer	CCLE	CRQTLGTLS	DEG_APCC_DBOX_1	0.1667
p.R1385G	ACH-001339	Skin Cancer	CCLE	CRQTLGTLS	DEG_APCC_DBOX_1	0.1667
p.R1385G	COLO-800	skin	COSMIC	CRQTLGTLS	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: CRQTLGTLS

Degron related mutations and impact score

Drug responses associated with ZNF831 mutations

All proteins holding degron of CRQTLGTLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JPB2	Zinc finger protein 831	DEG_APCC_DBOX_1	1371:1379	CRQTLGTLS	APC,CDC20,FZR1	0.7687	More...