DegronMD

Uniprot ID: Q12913

Source protein: Receptor-type tyrosine-protein phosphatase eta

Source gene: PTPRJ

Class: DEG_APCC_DBOX_1

Location: 236:244

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6143

ASA_SCORE: 32.2889

COIL: 0.1347

CONS_SCORE: 0.407

DSS_SCORE: 0.3189

HELIX: 0.012

FCONS_SCORE: 1.0087

RIG_SCORE: 0.8032

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A234T	TCGA-AX-A1CE	UCEC	TCGA	CRVLLESIG	DEG_APCC_DBOX_1	0.2778
p.A234T	TCGA-B7-5818	STAD	TCGA	CRVLLESIG	DEG_APCC_DBOX_1	0.2778
p.A234T	DO38883	STAD	ICGC	CRVLLESIG	DEG_APCC_DBOX_1	0.2778
p.A234T	DO42280	UCEC	ICGC	CRVLLESIG	DEG_APCC_DBOX_1	0.2778
p.A234T	SIDM01004	Chronic Myelogenous Leukemia	GDSC	CRVLLESIG	DEG_APCC_DBOX_1	0.2778
p.A234T	ACH-000983	Leukemia	CCLE	CRVLLESIG	DEG_APCC_DBOX_1	0.2778
p.A234T	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	CRVLLESIG	DEG_APCC_DBOX_1	0.2778
p.S245N	TCGA-BR-4184	STAD	TCGA	CRVLLESIG	DEG_APCC_DBOX_1	0.3056
p.S245N	DO38328	STAD	ICGC	CRVLLESIG	DEG_APCC_DBOX_1	0.3056
p.R254I	TCGA-CA-6717	COAD	TCGA	CRVLLESIG	DEG_APCC_DBOX_1	0.0556
p.R254I	DO8264	COAD	ICGC	CRVLLESIG	DEG_APCC_DBOX_1	0.0556
p.R237W	TCGA-D1-A17L	UCEC	TCGA	CRVLLESIG	DEG_APCC_DBOX_1	0.8634
p.R237W	DO40847	UCEC	ICGC	CRVLLESIG	DEG_APCC_DBOX_1	0.8634
p.R237W	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	CRVLLESIG	DEG_APCC_DBOX_1	0.8634
p.R237W	ACH-000158	Lymphoma	CCLE	CRVLLESIG	DEG_APCC_DBOX_1	0.8634
p.E247K	TCGA-D3-A2JF	SKCM	TCGA	CRVLLESIG	DEG_APCC_DBOX_1	0.25
p.E247K	DO38153	SKCM	ICGC	CRVLLESIG	DEG_APCC_DBOX_1	0.25
p.G230D	TCGA-XK-AAIW	PRAD	TCGA	CRVLLESIG	DEG_APCC_DBOX_1	0.1667
p.G230D	DO51407	PRAD	ICGC	CRVLLESIG	DEG_APCC_DBOX_1	0.1667
p.S228G	DO233205	GACA	ICGC	CRVLLESIG	DEG_APCC_DBOX_1	0.1111
p.H246L	DO233913	GACA	ICGC	CRVLLESIG	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12913	Receptor-type tyrosine-protein phosphatase eta	DEG_APCC_DBOX_1	236:244	CRVLLESIG	APC,CDC20,FZR1	0.6143	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons