DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DAAEGGKVPSP
Uniprot ID:
Q5JWF2
Source protein:
Guanine nucleotide-binding protein G
Source gene:
GNAS
Class:
DEG_COP1_1
Location:
366:376
E3 ligase:
COP1
DEGRON score:
0.9877
ASA_SCORE:
83.1182
COIL:
0.7997
CONS_SCORE:
0.4204
DSS_SCORE:
0.6192
HELIX:
0.1534
FCONS_SCORE:
1.0781
RIG_SCORE:
0.5951
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with GNAS mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DAAEGGKVPSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5JWF2
Guanine nucleotide-binding protein G
DEG_COP1_1
366:376
DAAEGGKVPSP
COP1
0.9877
More...