DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DAEEYTDLP
Uniprot ID:
Q8N3C0
Source protein:
Activating signal cointegrator 1 complex subunit 3
Source gene:
ASCC3
Class:
CBL_PTK
Location:
1851:1859
E3 ligase:
CBL
DEGRON score:
0.6288
ASA_SCORE:
62.7222
COIL:
0.5907
CONS_SCORE:
0.5348
DSS_SCORE:
0.3928
HELIX:
0.3846
FCONS_SCORE:
1.077
RIG_SCORE:
0.7504
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E1853K
TCGA-E2-A2P6
BRCA
TCGA
DAEEYTDLP
CBL_PTK
0.591
p.E1853K
DO4173
BRCA
ICGC
DAEEYTDLP
CBL_PTK
0.591
p.A1852T
DO222874
COCA
ICGC
DAEEYTDLP
CBL_PTK
0.6028
p.N1863Y
DO231992
LICA
ICGC
DAEEYTDLP
CBL_PTK
0.2222
p.P1859T
DO229035
LICA
ICGC
DAEEYTDLP
CBL_PTK
0.7031
p.E1843K
DO229213
THCA
ICGC
DAEEYTDLP
CBL_PTK
0.1111
p.S1850I
SIDM01696
Mesothelioma
GDSC
DAEEYTDLP
CBL_PTK
0.3056
Drug responses associated with ASCC3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DAEEYTDLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N3C0
Activating signal cointegrator 1 complex subunit 3
CBL_PTK
1851:1859
DAEEYTDLP
CBL
0.6288
More...
