DegronMD

Uniprot ID: P22079

Source protein: Lactoperoxidase

Source gene: LPO

Class: CBL_PTK

Location: 305:314

E3 ligase: CBL

DEGRON score: 0.6598

ASA_SCORE: 49.44

COIL: 0.5373

CONS_SCORE: 0.7025

DSS_SCORE: 0.1156

HELIX: 0.4082

FCONS_SCORE: 1.2316

RIG_SCORE: 0.7969

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R319H	TCGA-19-5956	GBM	TCGA	DASFVYSSEP	CBL_PTK	0.1944
p.Q296H	TCGA-23-2079	OV	TCGA	DASFVYSSEP	CBL_PTK	0.0833
p.R321C	TCGA-AR-A0TZ	BRCA	TCGA	DASFVYSSEP	CBL_PTK	0.1389
p.R321C	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DASFVYSSEP	CBL_PTK	0.1389
p.R321C	ACH-000918	Leukemia	CCLE	DASFVYSSEP	CBL_PTK	0.1389
p.R321C	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	DASFVYSSEP	CBL_PTK	0.1389
p.R321H	TCGA-CM-6675	COAD	TCGA	DASFVYSSEP	CBL_PTK	0.1389
p.R319S	TCGA-D3-A2J8	SKCM	TCGA	DASFVYSSEP	CBL_PTK	0.1944
p.S324I	TCGA-DF-A2KN	UCEC	TCGA	DASFVYSSEP	CBL_PTK	0.0556
p.A299V	TCGA-E6-A1LX	UCEC	TCGA	DASFVYSSEP	CBL_PTK	0.1667
p.S302F	TCGA-FR-A726	SKCM	TCGA	DASFVYSSEP	CBL_PTK	0.25
p.S302F	SIDM00545	Melanoma	GDSC	DASFVYSSEP	CBL_PTK	0.25
p.S302F	ACH-000987	Skin Cancer	CCLE	DASFVYSSEP	CBL_PTK	0.25
p.S302F	Mewo	skin	COSMIC	DASFVYSSEP	CBL_PTK	0.25
p.R321S	TCGA-ZG-A9L5	PRAD	TCGA	DASFVYSSEP	CBL_PTK	0.1389
p.A311T	DO230309	COCA	ICGC	DASFVYSSEP	CBL_PTK	0.7139
p.E306K	DO12196	GBM	ICGC	DASFVYSSEP	CBL_PTK	0.7022
p.R316K	DO28206	OV	ICGC	DASFVYSSEP	CBL_PTK	0.2778
p.R316K	DO37412	SKCM	ICGC	DASFVYSSEP	CBL_PTK	0.2778
p.R305H	DO219784	UCEC	ICGC	DASFVYSSEP	CBL_PTK	0.8244
p.S311N	SIDM00120	Prostate Carcinoma	GDSC	DASFVYSSEP	CBL_PTK	0.7069
p.S311N	ACH-000979	Prostate Cancer	CCLE	DASFVYSSEP	CBL_PTK	0.7069
p.S311N	DU-145	prostate	COSMIC	DASFVYSSEP	CBL_PTK	0.7069
p.A309V	NCI-H1155	lung	COSMIC	DASFVYSSEP	CBL_PTK	0.6936
p.F307L	CP66-MEL	skin	COSMIC	DASFVYSSEP	CBL_PTK	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22079	Lactoperoxidase	CBL_PTK	305:314	DASFVYSSEP	CBL	0.6598	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons