DegronMD

Uniprot ID: P46940

Source protein: Ras GTPase-activating-like protein IQGAP1

Source gene: IQGAP1

Class: DEG_COP1_1

Location: 1329:1337

E3 ligase: COP1

DEGRON score: 0.734

ASA_SCORE: 61.3889

COIL: 0.6877

CONS_SCORE: 0.3553

DSS_SCORE: 0.4099

HELIX: 0.2978

FCONS_SCORE: 0.9151

RIG_SCORE: 0.7534

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1323A	TCGA-P3-A5Q5	HNSC	TCGA	DDLGEVPTI	DEG_COP1_1	0.1667
p.D1330N	DO234336	ESAD	ICGC	DDLGEVPTI	DEG_COP1_1	0.6932
p.S1345F	ACH-000649	Kidney Cancer	CCLE	DDLGEVPTI	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46940	Ras GTPase-activating-like protein IQGAP1	DEG_COP1_1	1329:1337	DDLGEVPTI	COP1	0.734	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons