DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DDPLPDYSLPP
Uniprot ID:
Q12948
Source protein:
Forkhead box protein C1
Source gene:
FOXC1
Class:
CBL_PTK
Location:
425:435
E3 ligase:
CBL
DEGRON score:
0.9723
ASA_SCORE:
86.0182
COIL:
0.9509
CONS_SCORE:
0.2859
DSS_SCORE:
0.6535
HELIX:
0.0213
FCONS_SCORE:
0.8654
RIG_SCORE:
0.6985
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S441L
DO222834
BTCA
ICGC
DDPLPDYSLPP
CBL_PTK
0.1667
p.G421V
DO50875
LICA
ICGC
DDPLPDYSLPP
CBL_PTK
0.2222
p.G417A
DO229227
THCA
ICGC
DDPLPDYSLPP
CBL_PTK
0.1111
p.G417R
DO229227
THCA
ICGC
DDPLPDYSLPP
CBL_PTK
0.1111
p.A415T
ACH-001341
Cervical Cancer
CCLE
DDPLPDYSLPP
CBL_PTK
0.0556
Drug responses associated with FOXC1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DDPLPDYSLPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q12948
Forkhead box protein C1
CBL_PTK
425:435
DDPLPDYSLPP
CBL
0.9723
More...
