DegronMD

Uniprot ID: P00533

Source protein: Epidermal growth factor receptor

Source gene: EGFR

Class: DEG_COP1_1

Location: 1083:1092

E3 ligase: COP1

DEGRON score: 0.9978

ASA_SCORE: 90.14

COIL: 0.803

CONS_SCORE: 0.3338

DSS_SCORE: 0.4942

HELIX: 0.1815

FCONS_SCORE: 1.225

RIG_SCORE: 0.8013

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1085N	SIDM00329	Hodgkin's Lymphoma	GDSC	DDTFLPVPEY	DEG_COP1_1	0.8166
p.T1085N	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	DDTFLPVPEY	DEG_COP1_1	0.8166
p.D1087H	DO233726	GACA	ICGC	DDTFLPVPEY	DEG_COP1_1	0.7688
p.S1085G	NCI-H2172	lung	COSMIC	DDTFLPVPEY	DEG_COP1_1	0.6993
p.A1086V	SIDM00429	B-Lymphoblastic Leukemia	GDSC	DDTFLPVPEY	DEG_COP1_1	0.6936
p.A1086V	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	DDTFLPVPEY	DEG_COP1_1	0.6936
p.E1083D	DO222875	MELA	ICGC	DDTFLPVPEY	DEG_COP1_1	0.6758
p.S1096F	TCGA-D5-6928	COAD	TCGA	DDTFLPVPEY	DEG_COP1_1	0.6667
p.S1096F	DO7776	COAD	ICGC	DDTFLPVPEY	DEG_COP1_1	0.6667
p.D1084N	TCGA-A5-A0G1	UCEC	TCGA	DDTFLPVPEY	DEG_COP1_1	0.5821
p.D1082N	NCI-H1568	lung	COSMIC	DDTFLPVPEY	DEG_COP1_1	0.3056
p.N1094S	TCGA-DI-A1BU	UCEC	TCGA	DDTFLPVPEY	DEG_COP1_1	0.2778
p.N1094S	DO42023	UCEC	ICGC	DDTFLPVPEY	DEG_COP1_1	0.2778
p.E1079K	TCGA-DK-A3WW	BLCA	TCGA	DDTFLPVPEY	DEG_COP1_1	0.2222
p.V1097I	TCGA-AD-6964	COAD	TCGA	DDTFLPVPEY	DEG_COP1_1	0.1944
p.V1097I	TCGA-C5-A2M2	CESC	TCGA	DDTFLPVPEY	DEG_COP1_1	0.1944
p.V1097I	DO48984	CESC	ICGC	DDTFLPVPEY	DEG_COP1_1	0.1944
p.V1097I	DO8360	COAD	ICGC	DDTFLPVPEY	DEG_COP1_1	0.1944
p.A1076T	SIDM00429	B-Lymphoblastic Leukemia	GDSC	DDTFLPVPEY	DEG_COP1_1	0.1389
p.A1076T	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	DDTFLPVPEY	DEG_COP1_1	0.1389
p.L1075I	DO232224	PBCA	ICGC	DDTFLPVPEY	DEG_COP1_1	0.1111

Showing 1 to 21 of 21 entries

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Drug responses associated with EGFR mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	Erlotinib	10.6393
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	Lapatinib	5.8459
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	CUDC-101	0.1326
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	Pelitinib	0.4153
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	Foretinib	0.46
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	CI-1033	4.9765
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	PF-00299804	2.5703
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	AST-1306	5.3078
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	Gefitinib	2.2944
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	Afatinib	2.7142
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	Cetuximab	413.9756
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	Afatinib	20.0598
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	AZD8931	10.8315
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	Gefitinib	21.166
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	Afatinib	5.736
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	Erlotinib	7.3006
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	Sapitinib	47.179
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	Lapatinib	20.605
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	AZD3759	14.072
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	Osimertinib	4.7322
SIDM00145	ALL\|lymphoblastic_leukemia	p.E513fs*55 (No)	GDSC	Foretinib	0.4244
SIDM00121	ALL\|lymphoblastic_leukemia	p.A1118T (No)	GDSC	Erlotinib	15.278
SIDM00121	ALL\|lymphoblastic_leukemia	p.A1118T (No)	GDSC	Lapatinib	14.7118
SIDM00121	ALL\|lymphoblastic_leukemia	p.A1118T (No)	GDSC	CUDC-101	0.0671
SIDM00121	ALL\|lymphoblastic_leukemia	p.A1118T (No)	GDSC	Pelitinib	0.4033

Showing 1 to 25 of 2,263 entries

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All proteins holding degron of DDTFLPVPEY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P00533	Epidermal growth factor receptor	DEG_COP1_1	1083:1092	DDTFLPVPEY	COP1	0.9978	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DDTFLPVPEY

Degron related mutations and impact score

Drug responses associated with EGFR mutations

All proteins holding degron of DDTFLPVPEY