DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DEDLLGVPDGP
Uniprot ID:
Q9H1C4
Source protein:
Protein unc-93 homolog B1
Source gene:
UNC93B1
Class:
DEG_COP1_1
Location:
19:29
E3 ligase:
COP1
DEGRON score:
0.9236
ASA_SCORE:
77.2545
COIL:
0.8533
CONS_SCORE:
0.437
DSS_SCORE:
0.735
HELIX:
0.1076
FCONS_SCORE:
0.8021
RIG_SCORE:
0.6518
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A39T
DO229043
LICA
ICGC
DEDLLGVPDGP
DEG_COP1_1
0.0556
p.G28E
DO50921
LICA
ICGC
DEDLLGVPDGP
DEG_COP1_1
0.7199
Drug responses associated with UNC93B1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DEDLLGVPDGP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H1C4
Protein unc-93 homolog B1
DEG_COP1_1
19:29
DEDLLGVPDGP
COP1
0.9236
More...