DegronMD

Uniprot ID: Q8IVL5

Source protein: Prolyl 3-hydroxylase 2

Source gene: P3H2

Class: DEG_COP1_1

Location: 407:415

E3 ligase: COP1

DEGRON score: 0.8245

ASA_SCORE: 75.5778

COIL: 0.8234

CONS_SCORE: 0.3555

DSS_SCORE: 0.4396

HELIX: 0.087

FCONS_SCORE: 1.1772

RIG_SCORE: 0.7096

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E408K	SIDM00656	Burkitt's Lymphoma	GDSC	DENRVPSGV	DEG_COP1_1	0.7022
p.E408K	SIDM00641	Burkitt's Lymphoma	GDSC	DENRVPSGV	DEG_COP1_1	0.7022
p.G403R	SIDM00516	Melanoma	GDSC	DENRVPSGV	DEG_COP1_1	0.2222
p.G419V	SIDM00528	Breast Carcinoma	GDSC	DENRVPSGV	DEG_COP1_1	0.2222
p.G419V	MDA-MB-361	breast	COSMIC	DENRVPSGV	DEG_COP1_1	0.2222
p.N402S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DENRVPSGV	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVL5	Prolyl 3-hydroxylase 2	DEG_COP1_1	407:415	DENRVPSGV	COP1	0.8245	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons