DegronMD

Uniprot ID: Q49AN0

Source protein: Cryptochrome-2

Source gene: CRY2

Class: DEG_COP1_1

Location: 206:214

E3 ligase: COP1

DEGRON score: 0.9942

ASA_SCORE: 56.2778

COIL: 0.7821

CONS_SCORE: 0.3644

DSS_SCORE: 0.5563

HELIX: 0.1581

FCONS_SCORE: 1.0125

RIG_SCORE: 0.7473

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R199H	TCGA-ND-A4WC	UCS	TCGA	DETYGVPSL	DEG_COP1_1	0.1389
p.E221D	TCGA-UE-A6QT	SARC	TCGA	DETYGVPSL	DEG_COP1_1	0.1389
p.S201F	DO220886	MELA	ICGC	DETYGVPSL	DEG_COP1_1	0.1944
p.R221C	DO42312	UCEC	ICGC	DETYGVPSL	DEG_COP1_1	0.1389
p.C218R	SIDM00572	Gastric Carcinoma	GDSC	DETYGVPSL	DEG_COP1_1	0.2222
p.C218R	ACH-000911	Gastric Cancer	CCLE	DETYGVPSL	DEG_COP1_1	0.2222
p.C218R	NUGC-3	stomach	COSMIC	DETYGVPSL	DEG_COP1_1	0.2222
p.I196L	SIDM00845	Burkitt's Lymphoma	GDSC	DETYGVPSL	DEG_COP1_1	0.5
p.I196L	SIDM00461	Acute Myeloid Leukemia	GDSC	DETYGVPSL	DEG_COP1_1	0.5
p.I196L	SIDM01519	Head and Neck Carcinoma	GDSC	DETYGVPSL	DEG_COP1_1	0.5
p.R219M	SIDM00498	Colorectal Carcinoma	GDSC	DETYGVPSL	DEG_COP1_1	0.1944
p.R219M	ACH-000970	Colon/Colorectal Cancer	CCLE	DETYGVPSL	DEG_COP1_1	0.1944
p.R219M	SNU-C5	large_intestine	COSMIC	DETYGVPSL	DEG_COP1_1	0.1944
p.T211P	ACH-000491	Colon/Colorectal Cancer	CCLE	DETYGVPSL	DEG_COP1_1	0.7031
p.C197R	NUGC-3	stomach	COSMIC	DETYGVPSL	DEG_COP1_1	0.0833
p.R198M	SNU-C5	large_intestine	COSMIC	DETYGVPSL	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q49AN0	Cryptochrome-2	DEG_COP1_1	206:214	DETYGVPSL	COP1	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons