DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
DFEWVYTDQP
Uniprot ID:
Q6QHC5
Source protein:
Sphingolipid delta
Source gene:
DEGS2
Class:
CBL_PTK
Location:
9:18
E3 ligase:
CBL
DEGRON score:
0.5763
ASA_SCORE:
74.66
COIL:
0.7009
CONS_SCORE:
0.6049
DSS_SCORE:
0.4368
HELIX:
0.124
FCONS_SCORE:
1.0975
RIG_SCORE:
0.7764
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E11Q
TCGA-E2-A1IN
BRCA
TCGA
DFEWVYTDQP
CBL_PTK
0.5633
p.E11Q
DO3134
BRCA
ICGC
DFEWVYTDQP
CBL_PTK
0.5633
p.S8N
DO229010
COCA
ICGC
DFEWVYTDQP
CBL_PTK
0.3056
p.S8N
DO229016
COCA
ICGC
DFEWVYTDQP
CBL_PTK
0.3056
p.S8N
DO229003
COCA
ICGC
DFEWVYTDQP
CBL_PTK
0.3056
p.S8N
DO229005
COCA
ICGC
DFEWVYTDQP
CBL_PTK
0.3056
p.S8N
DO229473
LAML
ICGC
DFEWVYTDQP
CBL_PTK
0.3056
p.W12C
DO228969
LICA
ICGC
DFEWVYTDQP
CBL_PTK
0.5889
p.S6G
ACH-001484
Leukemia
CCLE
DFEWVYTDQP
CBL_PTK
0.25
p.S6G
ACH-001485
Leukemia
CCLE
DFEWVYTDQP
CBL_PTK
0.25
Drug responses associated with DEGS2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DFEWVYTDQP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6QHC5
Sphingolipid delta
CBL_PTK
9:18
DFEWVYTDQP
CBL
0.5763
More...
