DegronMD

Uniprot ID: Q9NQG1

Source protein: Protein MANBAL

Source gene: MANBAL

Class: DEG_COP1_1

Location: 6:15

E3 ligase: COP1

DEGRON score: 0.9616

ASA_SCORE: 79.73

COIL: 0.9408

CONS_SCORE: 0.9041

DSS_SCORE: 0.3648

HELIX: 0.0284

FCONS_SCORE: 1.0246

RIG_SCORE: 0.7339

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G25R	TCGA-2F-A9KO	BLCA	TCGA	DFSPPEVPEP	DEG_COP1_1	0.0556
p.G25R	TCGA-DK-A3WW	BLCA	TCGA	DFSPPEVPEP	DEG_COP1_1	0.0556
p.G25R	TCGA-EE-A3J7	SKCM	TCGA	DFSPPEVPEP	DEG_COP1_1	0.0556
p.G25R	DO51859	BLCA	ICGC	DFSPPEVPEP	DEG_COP1_1	0.0556
p.G25R	DO481	BLCA	ICGC	DFSPPEVPEP	DEG_COP1_1	0.0556
p.G25R	DO48770	SKCM	ICGC	DFSPPEVPEP	DEG_COP1_1	0.0556
p.G25E	TCGA-A6-2686	COAD	TCGA	DFSPPEVPEP	DEG_COP1_1	0.0556
p.G25E	DO7828	COAD	ICGC	DFSPPEVPEP	DEG_COP1_1	0.0556
p.R23W	TCGA-A8-A09M	BRCA	TCGA	DFSPPEVPEP	DEG_COP1_1	0.1111
p.R23W	TCGA-CK-4951	COAD	TCGA	DFSPPEVPEP	DEG_COP1_1	0.1111
p.R23W	DO3852	BRCA	ICGC	DFSPPEVPEP	DEG_COP1_1	0.1111
p.R23W	DO10582	COAD	ICGC	DFSPPEVPEP	DEG_COP1_1	0.1111
p.P10L	TCGA-AJ-A3OK	UCEC	TCGA	DFSPPEVPEP	DEG_COP1_1	0.6471
p.P10L	DO43602	UCEC	ICGC	DFSPPEVPEP	DEG_COP1_1	0.6471
p.E19K	TCGA-JW-AAVH	CESC	TCGA	DFSPPEVPEP	DEG_COP1_1	0.2222
p.E19K	DO51605	CESC	ICGC	DFSPPEVPEP	DEG_COP1_1	0.2222
p.D6Y	DO229029	LICA	ICGC	DFSPPEVPEP	DEG_COP1_1	0.7325
p.D4Y	DO229029	LICA	ICGC	DFSPPEVPEP	DEG_COP1_1	0.2778
p.R23Q	DO48939	PBCA	ICGC	DFSPPEVPEP	DEG_COP1_1	0.1111
p.E14D	SIDM00516	Melanoma	GDSC	DFSPPEVPEP	DEG_COP1_1	0.5647
p.E14D	ACH-002166	Skin Cancer	CCLE	DFSPPEVPEP	DEG_COP1_1	0.5647
p.E14D	MZ7-mel	skin	COSMIC	DFSPPEVPEP	DEG_COP1_1	0.5647
p.P10R	ACH-002016	Eye Cancer	CCLE	DFSPPEVPEP	DEG_COP1_1	0.6401

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQG1	Protein MANBAL	DEG_COP1_1	6:15	DFSPPEVPEP	COP1	0.9616	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons