DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
DGGLYSSLP
Uniprot ID:
P08138
Source protein:
Tumor necrosis factor receptor superfamily member 16
Source gene:
NGFR
Class:
CBL_PTK
Location:
332:340
E3 ligase:
CBL
DEGRON score:
0.9823
ASA_SCORE:
56.0889
COIL:
0.7396
CONS_SCORE:
0.4784
DSS_SCORE:
0.5918
HELIX:
0.1587
FCONS_SCORE:
0.7529
RIG_SCORE:
0.65
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V347L
TCGA-04-1648
OV
TCGA
DGGLYSSLP
CBL_PTK
0.1389
p.G333R
TCGA-A6-5661
COAD
TCGA
DGGLYSSLP
CBL_PTK
0.6457
p.S325L
TCGA-AZ-4315
COAD
TCGA
DGGLYSSLP
CBL_PTK
0.5833
p.P332L
DO51550
KIRP
ICGC
DGGLYSSLP
CBL_PTK
0.7582
p.P332L
DO38711
STAD
ICGC
DGGLYSSLP
CBL_PTK
0.7582
p.G333V
SIDM01174
Cervical Carcinoma
GDSC
DGGLYSSLP
CBL_PTK
0.6421
p.G333V
ACH-001402
Cervical Cancer
CCLE
DGGLYSSLP
CBL_PTK
0.6421
p.G333V
SW756
cervix
COSMIC
DGGLYSSLP
CBL_PTK
0.6421
p.L339P
SIDM00537
Colorectal Carcinoma
GDSC
DGGLYSSLP
CBL_PTK
0.6471
p.L339P
ACH-000982
Colon/Colorectal Cancer
CCLE
DGGLYSSLP
CBL_PTK
0.6471
p.L339P
ACH-001345
Colon/Colorectal Cancer
CCLE
DGGLYSSLP
CBL_PTK
0.6471
p.L339P
GP5d
large_intestine
COSMIC
DGGLYSSLP
CBL_PTK
0.6471
p.P340S
SIDM01763
Rhabdomyosarcoma
GDSC
DGGLYSSLP
CBL_PTK
0.6752
Drug responses associated with NGFR mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DGGLYSSLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P08138
Tumor necrosis factor receptor superfamily member 16
CBL_PTK
332:340
DGGLYSSLP
CBL
0.9823
More...
