DegronMD

Uniprot ID: Q9H9G7

Source protein: Protein argonaute-3

Source gene: AGO3

Class: CBL_PTK

Location: 87:97

E3 ligase: CBL

DEGRON score: 0.5754

ASA_SCORE: 33.7

COIL: 0.4845

CONS_SCORE: 0.493

DSS_SCORE: 0.3332

HELIX: 0.0264

FCONS_SCORE: 1.3916

RIG_SCORE: 0.7837

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P99L	TCGA-B5-A11E	UCEC	TCGA	DGKRSLYTANP	CBL_PTK	0.2778
p.P99L	DO41644	UCEC	ICGC	DGKRSLYTANP	CBL_PTK	0.2778
p.R82H	TCGA-B5-A11H	UCEC	TCGA	DGKRSLYTANP	CBL_PTK	0.1944
p.R82H	TCGA-CG-4306	STAD	TCGA	DGKRSLYTANP	CBL_PTK	0.1944
p.R82H	TCGA-G4-6588	COAD	TCGA	DGKRSLYTANP	CBL_PTK	0.1944
p.R82H	DO10140	COAD	ICGC	DGKRSLYTANP	CBL_PTK	0.1944
p.R82H	DO38567	STAD	ICGC	DGKRSLYTANP	CBL_PTK	0.1944
p.R82H	DO42825	UCEC	ICGC	DGKRSLYTANP	CBL_PTK	0.1944
p.P99S	TCGA-ER-A19J	SKCM	TCGA	DGKRSLYTANP	CBL_PTK	0.2778
p.P99S	DO37426	SKCM	ICGC	DGKRSLYTANP	CBL_PTK	0.2778
p.L85V	DO14694	HNSC	ICGC	DGKRSLYTANP	CBL_PTK	0.2778
p.G88E	DO220860	MELA	ICGC	DGKRSLYTANP	CBL_PTK	0.6087
p.Y105S	DO218908	SKCA	ICGC	DGKRSLYTANP	CBL_PTK	0.1111
p.Y105S	DO231241	THCA	ICGC	DGKRSLYTANP	CBL_PTK	0.1111
p.Y89C	DO41331	UCEC	ICGC	DGKRSLYTANP	CBL_PTK	0.7087
p.Y89C	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DGKRSLYTANP	CBL_PTK	0.7087
p.L92I	SIDM00193	Colorectal Carcinoma	GDSC	DGKRSLYTANP	CBL_PTK	0.6063
p.L92I	ACH-000991	Colon/Colorectal Cancer	CCLE	DGKRSLYTANP	CBL_PTK	0.6063
p.L92I	SNU-81	large_intestine	COSMIC	DGKRSLYTANP	CBL_PTK	0.6063
p.G88R	ACH-000694	Esophageal Cancer	CCLE	DGKRSLYTANP	CBL_PTK	0.6457
p.P90L	ME-180	cervix	COSMIC	DGKRSLYTANP	CBL_PTK	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H9G7	Protein argonaute-3	CBL_PTK	87:97	DGKRSLYTANP	CBL	0.5754	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons