DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
DGRKNLYTAMP
Uniprot ID:
Q9UKV8
Source protein:
Protein argonaute-2
Source gene:
AGO2
Class:
CBL_PTK
Location:
95:105
E3 ligase:
CBL
DEGRON score:
0.7256
ASA_SCORE:
51.4818
COIL:
0.5714
CONS_SCORE:
0.5079
DSS_SCORE:
0.2991
HELIX:
0.0379
FCONS_SCORE:
1.3878
RIG_SCORE:
0.8052
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G96S
TCGA-4Z-AA82
BLCA
TCGA
DGRKNLYTAMP
CBL_PTK
0.5882
p.G96S
DO218987
BLCA
ICGC
DGRKNLYTAMP
CBL_PTK
0.5882
p.E114D
TCGA-A8-A09Z
BRCA
TCGA
DGRKNLYTAMP
CBL_PTK
0.0833
p.E114D
DO5521
BRCA
ICGC
DGRKNLYTAMP
CBL_PTK
0.0833
p.P107L
TCGA-B5-A0JY
UCEC
TCGA
DGRKNLYTAMP
CBL_PTK
0.2778
p.P107L
TCGA-EO-A3B0
UCEC
TCGA
DGRKNLYTAMP
CBL_PTK
0.2778
p.P107L
DO219773
UCEC
ICGC
DGRKNLYTAMP
CBL_PTK
0.2778
p.P107L
DO43041
UCEC
ICGC
DGRKNLYTAMP
CBL_PTK
0.2778
p.R97S
TCGA-VS-A9UM
CESC
TCGA
DGRKNLYTAMP
CBL_PTK
0.6316
p.R97S
DO51644
CESC
ICGC
DGRKNLYTAMP
CBL_PTK
0.6316
p.K112N
TCGA-ZF-A9R0
BLCA
TCGA
DGRKNLYTAMP
CBL_PTK
0.25
p.V93M
DO222500
ESCA
ICGC
DGRKNLYTAMP
CBL_PTK
0.2778
p.D111E
DO228974
LICA
ICGC
DGRKNLYTAMP
CBL_PTK
0.1667
p.T102K
DO229019
LICA
ICGC
DGRKNLYTAMP
CBL_PTK
0.7306
p.P107T
DO229037
LICA
ICGC
DGRKNLYTAMP
CBL_PTK
0.2778
p.E114G
SIDM00901
Endometrial Carcinoma
GDSC
DGRKNLYTAMP
CBL_PTK
0.0833
p.E114G
ACH-000940
Endometrial/Uterine Cancer
CCLE
DGRKNLYTAMP
CBL_PTK
0.0833
p.E114G
AN3-CA
endometrium
COSMIC
DGRKNLYTAMP
CBL_PTK
0.0833
p.D89N
ACH-001561
Lung Cancer
CCLE
DGRKNLYTAMP
CBL_PTK
0.1667
Drug responses associated with AGO2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DGRKNLYTAMP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UKV8
Protein argonaute-2
CBL_PTK
95:105
DGRKNLYTAMP
CBL
0.7256
More...
