DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DGYDYTVSP
Uniprot ID:
Q7LC44
Source protein:
Activity-regulated cytoskeleton-associated protein
Source gene:
ARC
Class:
CBL_PTK
Location:
163:171
E3 ligase:
CBL
DEGRON score:
0.6237
ASA_SCORE:
87.9333
COIL:
0.8933
CONS_SCORE:
0.5064
DSS_SCORE:
0.4284
HELIX:
0.0229
FCONS_SCORE:
0.8738
RIG_SCORE:
0.7593
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V169I
DO44966
LIHC
ICGC
DGYDYTVSP
CBL_PTK
0.5965
p.S170N
TCGA-D1-A103
UCEC
TCGA
DGYDYTVSP
CBL_PTK
0.5958
p.S170N
DO42312
UCEC
ICGC
DGYDYTVSP
CBL_PTK
0.5958
p.D166E
DO50341
ESAD
ICGC
DGYDYTVSP
CBL_PTK
0.5647
p.E161K
DO222798
COCA
ICGC
DGYDYTVSP
CBL_PTK
0.2778
p.T175P
DO229467
SKCA
ICGC
DGYDYTVSP
CBL_PTK
0.2222
p.P176L
TCGA-CV-7406
HNSC
TCGA
DGYDYTVSP
CBL_PTK
0.1944
p.P176L
DO15422
HNSC
ICGC
DGYDYTVSP
CBL_PTK
0.1944
p.A180T
TCGA-FF-A7CX
DLBC
TCGA
DGYDYTVSP
CBL_PTK
0.0833
p.A180T
DO219896
DLBC
ICGC
DGYDYTVSP
CBL_PTK
0.0833
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Drug responses associated with ARC mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of DGYDYTVSP
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7LC44
Activity-regulated cytoskeleton-associated protein
CBL_PTK
163:171
DGYDYTVSP
CBL
0.6237
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