DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
DGYDYTVSP
Uniprot ID:
Q7LC44
Source protein:
Activity-regulated cytoskeleton-associated protein
Source gene:
ARC
Class:
CBL_PTK
Location:
163:171
E3 ligase:
CBL
DEGRON score:
0.6237
ASA_SCORE:
87.9333
COIL:
0.8933
CONS_SCORE:
0.5064
DSS_SCORE:
0.4284
HELIX:
0.0229
FCONS_SCORE:
0.8738
RIG_SCORE:
0.7593
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P176L
TCGA-CV-7406
HNSC
TCGA
DGYDYTVSP
CBL_PTK
0.1944
p.P176L
DO15422
HNSC
ICGC
DGYDYTVSP
CBL_PTK
0.1944
p.S170N
TCGA-D1-A103
UCEC
TCGA
DGYDYTVSP
CBL_PTK
0.5958
p.S170N
DO42312
UCEC
ICGC
DGYDYTVSP
CBL_PTK
0.5958
p.A180T
TCGA-FF-A7CX
DLBC
TCGA
DGYDYTVSP
CBL_PTK
0.0833
p.A180T
DO219896
DLBC
ICGC
DGYDYTVSP
CBL_PTK
0.0833
p.E161K
DO222798
COCA
ICGC
DGYDYTVSP
CBL_PTK
0.2778
p.D166E
DO50341
ESAD
ICGC
DGYDYTVSP
CBL_PTK
0.5647
p.V169I
DO44966
LIHC
ICGC
DGYDYTVSP
CBL_PTK
0.5965
p.T175P
DO229467
SKCA
ICGC
DGYDYTVSP
CBL_PTK
0.2222
Drug responses associated with ARC mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DGYDYTVSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7LC44
Activity-regulated cytoskeleton-associated protein
CBL_PTK
163:171
DGYDYTVSP
CBL
0.6237
More...
