DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DHGAYSQSP
Uniprot ID:
Q9Y4B6
Source protein:
DDB1- and CUL4-associated factor 1
Source gene:
DCAF1
Class:
CBL_PTK
Location:
980:988
E3 ligase:
CBL
DEGRON score:
0.9819
ASA_SCORE:
83.3222
COIL:
0.7707
CONS_SCORE:
0.299
DSS_SCORE:
0.5817
HELIX:
0.1827
FCONS_SCORE:
1.0338
RIG_SCORE:
0.6408
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DCAF1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DHGAYSQSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y4B6
DDB1- and CUL4-associated factor 1
CBL_PTK
980:988
DHGAYSQSP
CBL
0.9819
More...
