DegronMD

Uniprot ID: O95786

Source protein: Antiviral innate immune response receptor RIG-I

Source gene: DDX58

Class: DEG_APCC_KENBOX_2

Location: 163:167

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6962

ASA_SCORE: 93.04

COIL: 0.6796

CONS_SCORE: 0.4525

DSS_SCORE: 0.1319

HELIX: 0.3254

FCONS_SCORE: 1.5156

RIG_SCORE: 0.7944

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I164V	DO26490	LUSC	ICGC	DKENW	DEG_APCC_KENBOX_2	0.7076
p.Q165K	DO229036	LICA	ICGC	DKENW	DEG_APCC_KENBOX_2	0.6944
p.L177R	DO41903	UCEC	ICGC	DKENW	DEG_APCC_KENBOX_2	0.5
p.P168S	TCGA-BR-7707	STAD	TCGA	DKENW	DEG_APCC_KENBOX_2	0.3056
p.Q175K	DO228976	LICA	ICGC	DKENW	DEG_APCC_KENBOX_2	0.1111
p.Q175K	DO37971	SKCM	ICGC	DKENW	DEG_APCC_KENBOX_2	0.1111
p.L155F	DO51407	PRAD	ICGC	DKENW	DEG_APCC_KENBOX_2	0.1111
p.E153D	TCGA-19-5956	GBM	TCGA	DKENW	DEG_APCC_KENBOX_2	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95786	Antiviral innate immune response receptor RIG-I	DEG_APCC_KENBOX_2	163:167	DKENW	APC,CDC20,FZR1	0.6962	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons