DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DKQPYSKLP
Uniprot ID:
Q16739
Source protein:
Ceramide glucosyltransferase
Source gene:
UGCG
Class:
CBL_PTK
Location:
43:51
E3 ligase:
CBL
DEGRON score:
0.6541
ASA_SCORE:
89.1778
COIL:
0.9297
CONS_SCORE:
0.3612
DSS_SCORE:
0.261
HELIX:
0.0448
FCONS_SCORE:
0.6976
RIG_SCORE:
0.7592
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L37I
TCGA-A5-A0G1
UCEC
TCGA
DKQPYSKLP
CBL_PTK
0.1667
p.L37I
DO42472
UCEC
ICGC
DKQPYSKLP
CBL_PTK
0.1667
p.A41V
DO228935
COCA
ICGC
DKQPYSKLP
CBL_PTK
0.2778
p.L37F
SIDM00581
Glioblastoma
GDSC
DKQPYSKLP
CBL_PTK
0.1667
p.L37F
ACH-000738
Brain Cancer
CCLE
DKQPYSKLP
CBL_PTK
0.1667
p.L37F
GB-1
central_nervous_system
COSMIC
DKQPYSKLP
CBL_PTK
0.1667
p.R34Q
ACH-000314
Lung Cancer
CCLE
DKQPYSKLP
CBL_PTK
0.0833
Drug responses associated with UGCG mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DKQPYSKLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q16739
Ceramide glucosyltransferase
CBL_PTK
43:51
DKQPYSKLP
CBL
0.6541
More...
